95041-53-5Relevant articles and documents
A mild and rapid glycosylation reaction between pyrimidine bases and 2-deoxyribofuranosyl N,N,N',N'-tetramethylphosphoroamidates
Iimori, Takamasa,Kobayashi, Hiroshi,Hashimoto, Shun-Ichi,Ikegami, Shiro
, p. 485 - 488 (2007/10/03)
A trimethylsilyl triflate-mediated coupling reaction to produce protected 2′-deoxynucleosides has been developed by using N,N,N',N'-tetramethylphosphoroamidate as a leaving group. In this reaction, employment of a 3,4,5-trimethoxybenzoyl group as the 3-hydroxyl protective group in the sugar moiety improved the β-stereoselectivity via a novel 1,3-participation.
Improved procedure for the regiospecific synthesis of 2'-deoxyribonucleosides
Baud,Chavis,Lucas,Imbach
, p. 4437 - 4440 (2007/10/02)
2'-Deoxyribonucleosides are regiospecifically synthesized in high yields by catalyzing with KI-dibenzo-18-crown-6 PTC the condensation between unprotected silylated purines and pyrimidines and the appropriate easily available 2-deoxy-ribofuranosyl or pyranosyl sugar derivatives.