186797-58-0

Basic information

• Product Name: 2-(benzyloxy)-5-broMobenzenaMine
• Synonyms: 2-(benzyloxy)-5-broMobenzenaMine;2-Benzyloxy-5-bromobenzamine
• CAS NO: 186797-58-0
• Molecular Formula: C₁₃H₁₂BrNO
• Molecular Weight: 278.14448
• Mol File: 186797-58-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(benzyloxy)-5-broMobenzenaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxy)-5-broMobenzenaMine(186797-58-0)
• EPA Substance Registry System: 2-(benzyloxy)-5-broMobenzenaMine(186797-58-0)

Safety Data

• Hazardous Substances Data: 186797-58-0(Hazardous Substances Data)

Usage

Derivative of aniline

A modified form of the aniline molecule, with alterations in its structure.

Benzene ring

A six-carbon ring with alternating single and double bonds, forming the backbone of the compound.

Bromine substituent at the 5-position

A bromine atom attached to the fifth carbon of the benzene ring, influencing the compound's reactivity and properties.

Benzyloxy group at the 2-position

A benzyl (C7H7) group connected to an oxygen atom, attached to the second carbon of the benzene ring, affecting the compound's reactivity and properties.

Common use in organic synthesis and pharmaceutical research

The compound is frequently utilized as a building block or reagent in the creation of more complex organic molecules and pharmaceuticals due to its reactivity.

Potential pharmacological properties

The compound may exhibit biological activity or therapeutic effects, making it a subject of interest in drug development.

Classified as a hazardous chemical

Due to its potential risks and dangers, the compound is categorized as hazardous, requiring proper handling and storage.

Requires proper safety precautions and controlled laboratory environment

To minimize risks and ensure safety, the compound should be handled with care, using appropriate personal protective equipment and working in a controlled laboratory setting.

Upstream product

• 100-39-0 benzyl bromide 
• 7693-52-9 4-bromo-2-nitrophenol 
• 106-41-2 4-bromo-phenol 
• 383868-64-2 1-(benzyloxy)-4-bromo-2-nitrobenzene 

Downstream Products

• 941311-11-1 5-(2-benzyloxy-5-bromophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one 
• 941311-13-3 2-[4-hydroxy-3-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-pyrrole-1-carboxylic acid tert-butyl ester 
• 941311-18-8 5-(3'-amino-4-benzyloxybiphenyl-3-yl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one 
• 941311-44-0 5-(4-benzyloxy-4'-hydroxymethylbiphenyl-3-yl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one 
• 941311-42-8 5-[2-benzyloxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one 
• 941311-09-7 2-benzyloxy-5-bromophenyl-N-(t-butoxycarbonylsulfamoyl)-acetic acid ethyl ester 
• 941311-16-6 methanesulfonic acid 4'-benzyloxy-3'-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-biphenyl-3-yl ester 
• 941311-33-7 5-[2-benzyloxy-5-(4-fluorophenylethynyl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one 
• 941311-12-2 2-[4-benzyloxy-3-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-pyrrole-1-carboxylic acid tert-butyl ester 
• 941311-23-5 1-[4'-benzyloxy-3'-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-biphenyl-3-yl]-3-ethyl-urea 
• 941311-22-4 N-[4'-benzyloxy-3'-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-biphenyl-3-yl]-2,2,2-trifluoroacetamide 
• 941311-41-7 2-benzyloxy-6-{4-[4-benzyloxy-3-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-butoxy}-N,N-dimethylbenzamide 
• 941311-08-6 (2-benzyloxy-5-bromophenylamino)-acetic acid ethyl ester 
• 955950-57-9 1-Benzyloxy-4-bromo-2-isothiocyanato-benzene 

Relevant articles and documents

IDO INHIBITORS

There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

A practical nickel-catalyzed reductive alkylation of amidophenyl bromides

A modified Weix's reductive coupling for alkylation of amidoaryl bromides based on Ni(COD)2 precatalyst and 2,2′-dipyridyl ligand was developed. This reaction is reliable for amidophenyl bromides and gives yields up to 87%, and is potentially useful in the synthesis of amidophenyl-containing molecules.

l , l , 3-TRI0X0-l , 2 , 5-THIADIAZ0LIDINES AND THEIR USE AS PTP-ASES INHIBITORS

Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inhibitors of other e

HETEROCYCLYL COMPOUNDS

Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, D, Z, R1, R2a , R2b, and Rx are as defined in the specification, a process for the preparation of such compounds, pharm