187543-87-9

Basic information

• Product Name: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
• Synonyms: 5,6-Difluoro-o-anisaldehyde;2,3-Difluoro-6-methoxybezaldehyde;3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde;2,3-DIFLUORO-6-METHOXYBENZALDEHYDE;2,3-Difluoro-6-methoxybenzaldehyde 98%;2,3-Difluoro-6-methoxybenzaldehyde98%;2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+%
• CAS NO: 187543-87-9
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• Product Categories: Fluorine series;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde
• Mol File: 187543-87-9.mol

Chemical Properties

• Melting Point: 55-57
• Boiling Point: 233°Cat760mmHg
• Flash Point: 92.1°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 0.0571mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE(187543-87-9)
• EPA Substance Registry System: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE(187543-87-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• Hazardous Substances Data: 187543-87-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Difluoro-6-methoxybenzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structural features, which can enhance the biological activity and selectivity of the resulting compounds.
Used in Agrochemical Industry:
2,3-Difluoro-6-methoxybenzaldehyde is used as a building block in the development of agrochemicals, contributing to the creation of novel pesticides and other crop protection agents with improved efficacy and selectivity.
Used in Organic Synthesis:
2,3-Difluoro-6-methoxybenzaldehyde serves as a versatile starting material in organic synthesis, enabling the preparation of a wide range of chemical compounds with diverse applications in various industries.
Used in Drug Discovery and Development:
2,3-Difluoro-6-methoxybenzaldehyde is utilized by researchers and chemists as a valuable tool in drug discovery and development, providing a foundation for the design and synthesis of new therapeutic agents with potential applications in various medical fields.

InChI:InChI=1/C8H6F2O2/c1-12-7-3-2-6(9)8(10)5(7)4-11/h2-4H,1H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 115144-40-6 1,2-difluoro-4-methoxy-benzene 
• 2713-33-9 3,4-difluorophenol 
• 758-16-7 N,N-dimethylthioformamide 

Downstream Products

• 476199-02-7 methyl 7-fluoro-4-methoxy-1-benzothiophene-2-carboxylate 
• 476199-03-8 7-fluoro-4-methoxy-1-benzothiophene-2-carboxylic acid 
• 476199-75-4 4-(3-chloro-1-phenyl-propoxy)-7-fluoro-benzo[b]thiophene 
• 476199-46-9 4-(3-chloro-1-phenyl-propoxy)-7-fluoro-benzo[b]thiophene 
• 910394-72-8 2,3-difluoro-6-methoxyphenethylamine 
• 181305-41-9 1-(5-Bromo-pyridin-2-yl)-3-[2-(2,3-difluoro-6-methoxy-phenyl)-ethyl]-thiourea 
• 773873-26-0 2,3-difluoro-6-methoxybenzoic acid 
• 187543-89-1 2,3-difluoro-6-hydroxybenzaldehyde 
• 934180-41-3 7-fluoro-4-methoxy-benzo[d]isothiazole 
• 1056265-05-4 7-fluoro-4-(methyloxy)-1H-indazole 
• 741714-88-5 (2,4-Dichloro-pyrimidin-5-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanol 
• 1308661-88-2 2-(3-{[(2,3-difluoro-6-methoxy-benzyl)-((S)-1-dimethylaminomethyl-2-phenyl-ethyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid((1S,2S,3S,5R)-2,6,6-trimethyl-bicyclo[3.1.1]hept-3-yl)-amide 

Relevant articles and documents

A practical method for stabilizing lithiated halogenated aromatic compounds

An exothermic decomposition was observed during a metalation/acylation of 3,4-difluoroanisole (5), resulting in a significant thermal hazard. The lithiated anion 6 was found to decompose exothermically at temperatures above -47°C showing an adiabatic temp

TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R6, R7 and R8 are as defined herein.

2,3-difluoro-6-methoxybenzene process for the preparation of formaldehyde (by machine translation)

The invention discloses a 2,3-difluoro-6-methoxybenzene process for the preparation of formaldehyde, the compound 3,4-difluoroanisole steams newly methyl tetrahydrofuran is added in, weighing anhydrous magnesium chloride, stirring the mixture at room temp

SULTAM DERIVATIVES

The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.

METHODS FOR STABILIZING LITHIATED HALOGEN-SUBSTITUTED AROMATIC COMPOUNDS

The present invention provides novel methods for stabilizing lithiated halogen-substituted aromatic compounds. In particular, the method is useful for the preparation of 2-methoxy-5, 6-difluorobenzaldehyde, an important intermediate for the preparation of

INDAZOLES USED TO TREAT ESTROGEN RECEPTOR BETA MEDIATED DISORDERS

The present invention relates to novel indazole derivatives (I) having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.

3-ARYLOXY/ THIO-2, 3-SUBSTITUTED PROPANAMINES AND THEIR USE IN INHIBITING SEROTONIN AND NOREPINEPHRINE REUPTAKE

There is provided a compound of formula (I) wherein A is selected from -O- and -S-; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4 alkyl, and C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, -CF3, -CN and -CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4 alkyl; Z is selected from OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereofwith the proviso that when Y is optionally substituted phenyl or optionally substituted 1,3-benzodioxolyl and Z is OR3 and X is optionally substituted phenyl then A is -S-.

Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake

A series of benzothienyloxy phenylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.

Heterocyclcarboxamide derivatives and their use as therapeutic agents

Compounds of formula I STR1 and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R1 is an optional substituent; U is an alkylene chain optionally substituted by one or more alkyl; Q