189231-45-6

Basic information

• Product Name: 1H-Pyrrole-1-aceticacid,alpha,2-dimethyl-,methylester,(R)-(9CI)
• Synonyms: 1H-Pyrrole-1-aceticacid,alpha,2-dimethyl-,methylester,(R)-(9CI)
• CAS NO: 189231-45-6
• Molecular Formula: C9H13NO2
• Molecular Weight: 0
• Product Categories: GLYCINESCAFFOLD
• Mol File: 189231-45-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-1-aceticacid,alpha,2-dimethyl-,methylester,(R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-1-aceticacid,alpha,2-dimethyl-,methylester,(R)-(9CI)(189231-45-6)
• EPA Substance Registry System: 1H-Pyrrole-1-aceticacid,alpha,2-dimethyl-,methylester,(R)-(9CI)(189231-45-6)

Safety Data

• Hazardous Substances Data: 189231-45-6(Hazardous Substances Data)

Upstream product

• 14316-06-4 D-alanine methyl ester hydrochloride 
• 136571-61-4 1-methyl-4-chloro-2-butenal 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 10065-72-2 L-Alanine methyl ester 
• 75-36-5 acetyl chloride 
• 107-05-1 3-chloroprop-1-ene 

Relevant articles and documents

Clean and efficient microwave-solvent-free conversion of homochiral amines, α-amino alcohols and α-amino acids to their chiral 2-substituted pyrrole derivatives

Efficient synthesis of 1,2-disubstituted homochiral pyrroles has been achieved by a two-component coupling of chloroenones and amine compounds on the surface of silica gel without any solvent under microwave irradiation.

Conversion of homochiral amines, β-amino alcohols and α-amino acids to their chiral 2-substituted pyrrole derivatives

The conversion of the amino group of chiral amines, amino alcohols, amino acids and their esters into chiral 2-substituted pyrrole derivatives with various halogeno enones is described. The conversion works in good yield and without racemization. The synthesis of 2-phenylpyrrole derivatives was possible with amino alcohols but not with amino acids or their esters.

Conversion of homochiral amines, β-amino alcohols and α-amino acids to their chiral 2-methylpyrrole derivatives

5-Chloro-3-penten-2-one reacts with the amino group of homochiral amines, amino alcohols, amino acid esters to form corresponding 2-pyrrole derivatives in good yield and without racemization.