200616-40-6

Basic information

• Product Name: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester
• Synonyms: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester;N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-L-glutamic acid 5-tert-butyl ester;(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-5-tert-butoxy-5-oxopentanoic acid;REF DUPL: Fmoc-N-Me-Glu(OtBu)-OH;N-FMoc-N-Methyl-L-glutaMic acid 5-tert-butyl ester, 98%;Fmoc-N-methyl-L-glutamic acid γ-tert-butyl ester;Fmoc-N-Me-Glu(OtBu)-OH 97%;Fmoc-N-Me-L-Glu(OtBu)-OH
• CAS NO: 200616-40-6
• Molecular Formula: C25H29NO6
• Molecular Weight: 439.5
• Product Categories: N-Methyl Amino Acids;Fmoc-Amino acid series;amino acids;PROTECTED AMINO ACID & PEPTIDES;Glutamic acid [Glu, E]
• Mol File: 200616-40-6.mol

Chemical Properties

• Melting Point: 116-119°C
• Boiling Point: 612.3 °C at 760 mmHg
• Flash Point: 324.1 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 7.58E-16mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: -15°C
• PKA: 3.72±0.10(Predicted)
• CAS DataBase Reference: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester(200616-40-6)
• EPA Substance Registry System: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester(200616-40-6)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 200616-40-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester is used as a building block for the synthesis of peptides and proteins with improved stability. Its enhanced stability compared to standard amino acids makes it a valuable component in the development of more effective and longer-lasting pharmaceuticals.
Used in Research and Development:
In the field of research and development, Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester is used as a key compound in the study of peptide and protein structures, as well as their interactions with other biomolecules. Its unique properties allow scientists to explore new avenues in drug design and development.
Used in Drug Delivery Systems:
Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester can be utilized in the design of drug delivery systems, where its enhanced stability can contribute to the development of more efficient and targeted therapies. Its incorporation into drug carriers can potentially improve the bioavailability and therapeutic outcomes of various medications.
Used in Chemical Synthesis:
In the realm of chemical synthesis, Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester serves as an important intermediate for the production of various complex organic compounds, including those with potential applications in the pharmaceutical, agrochemical, and materials science industries.

InChI:InChI=1/C25H29NO6/c1-25(2,3)32-22(27)14-13-21(23(28)29)26(4)24(30)31-15-20-18-11-7-5-9-16(18)17-10-6-8-12-19(17)20/h5-12,20-21H,13-15H2,1-4H3,(H,28,29)/t21-/m0/s1

Upstream product

• 51644-83-8 N-(benzyloxy)carbonyl-D-glutamic acid 5-tert-butyl ester 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 140837-98-5 (R)-2-(((benzyloxy)carbonyl)(methyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid 
• 45125-00-6 (R)-2-amino-5-(tert-butoxy)-5-oxopentanoic acid 

Downstream Products

• 879551-17-4 2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-pentanedioic acid 

Relevant articles and documents

Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.