201145-98-4

Basic information

• Product Name: N-[4-(4-Chloro-phenylcarbamoyl)-3-methyl-isoxazol-5-yl]-formimidic acid methyl ester
• CAS NO: 201145-98-4
• Molecular Weight: 293.71
• Mol File: 201145-98-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[4-(4-Chloro-phenylcarbamoyl)-3-methyl-isoxazol-5-yl]-formimidic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(4-Chloro-phenylcarbamoyl)-3-methyl-isoxazol-5-yl]-formimidic acid methyl ester(201145-98-4)
• EPA Substance Registry System: N-[4-(4-Chloro-phenylcarbamoyl)-3-methyl-isoxazol-5-yl]-formimidic acid methyl ester(201145-98-4)

Safety Data

• Hazardous Substances Data: 201145-98-4(Hazardous Substances Data)

Upstream product

• 84661-32-5 5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide 
• 67-56-1 methanol 
• 201145-94-0 3-Methyl-5-[2,2,2-trichloro-eth-(E)-ylideneamino]-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide 

Downstream Products

• 201146-04-5 5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide 
• 201146-10-3 3-Methyl-5-[N-(5-methyl-pyridin-2-yl)-formimidoylamino]-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide 

Relevant articles and documents

Synthesis and structure elucidation of 5-aminomethinimino-3-methyl-4-isoxazolecarboxylic acid phenylamides and their immunological activity

A series of 5-aminomethinimino-3-methyl-4-isoxazolecarboxylic acid phenylamides 4 has been prepared by condensation of 5-amino-3-methyl-4-isoxazolecarboxylic acid phenylamides 1 with trichloroacetic aldehyde. Alcoholysis of trichloro derivatives 2 gave 5-alkoxymethine derivatives 3 which, on reaction with an appropriate amine, formed the corresponding compounds 4. The compounds obtained were evaluated for their immunological activity. The properties of three compounds, described in this report, permitted inhibition of the immune response in all possible ways: diminishing both types of immune response (4d), humoral immune response (4a), or cellular immune response (4c). Preparation 4d is comparable in its effectiveness to CsA, so it may be potentially used as an agent far prolongation of the function of transplanted organs. Two other compounds may potentially be used in cases where only one type the immune response is required for combating pathogen invasion.