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Cas Database

205491-14-1

205491-14-1

Identification

  • Product Name:methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

  • CAS Number: 205491-14-1

  • EINECS:

  • Molecular Weight:273.329

  • Molecular Formula: C13H23NO5

  • HS Code:

  • Mol File:205491-14-1.mol

Synonyms:methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

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Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:AK Scientific
  • Product Description:Tert-butyl(4S)-4-(2-methoxy-2-oxoethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
  • Packaging:1g
  • Price:$ 1133
  • Delivery:In stock
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  • Manufacture/Brand:Aaron Chemicals
  • Product Description:Methyl(S)-3-Boc-2,2-dimethyloxazolidine-4-acetate 99%
  • Packaging:10g
  • Price:$ 1942
  • Delivery:In stock
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  • Manufacture/Brand:Aaron Chemicals
  • Product Description:Methyl(S)-3-Boc-2,2-dimethyloxazolidine-4-acetate 99%
  • Packaging:5g
  • Price:$ 1167
  • Delivery:In stock
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  • Manufacture/Brand:Aaron Chemicals
  • Product Description:Methyl(S)-3-Boc-2,2-dimethyloxazolidine-4-acetate 99%
  • Packaging:1g
  • Price:$ 393
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Relevant articles and documentsAll total 4 Articles be found

NOVEL QUINOLINE-SUBSTITUTED COMPOUND

-

Paragraph 0596-0598, (2016/10/10)

An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.

NOVEL QUINOLINE -SUBSTITUTED COMPOUND

-

, (2016/08/10)

An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.

Orthogonally protected glycerols and 2-aminodiols: Useful building blocks in heterocyclic chemistry

Ollivier, Anthony,Goubert, Marlene,Tursun, Ahmatjan,Canet, Isabelle,Sinibaldia, Marie-Eve

experimental part, p. 108 - 126 (2010/10/03)

The efficient synthesis of orthogonally protected glycerols, 2-aminopropane-1,3-diols and 2-aminobutane-1,4-diols that can constitute useful tools in heterocyclic chemistry, is reported. These interesting tri-functionalized small synthons were easily prepared from serine or aspartic acid. In addition, these substrates can be readily transformed into their iodide derivatives in very good yields. ARKAT USA, Inc.

Novel route to the synthesis of hydroxylated pyrrolidine derivatives via the intramolecular reaction of γ-aminoallylstannane with aldehyde. Total synthesis of (+)-preussin

Kadota, Isao,Saya, Shioko,Yamamoto, Yoshinori

, p. 335 - 348 (2007/10/03)

The thermal cyclization of γ-aminoallylstannane (8) having an aldehyde group gave β-hydroxypyrrolidine derivative (9a) as a sole product. This methodology was applied successfully to the total synthesis of (+)-preussin.

Process route upstream and downstream products

Process route

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester
136703-59-8

(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
With toluene-4-sulfonic acid; In dichloromethane; Yield given; Ambient temperature;
With boron trifluoride diethyl etherate; In acetone; at 20 ℃; for 4h;
8.72 g
methyl (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxybutanoate
1062238-49-6

methyl (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxybutanoate

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
With boron trifluoride diethyl etherate; In acetone; at 20 ℃; for 4h;
8.72 g
methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-(tert-butyldiphenylsilyloxy)butanoate
869212-63-5

methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-(tert-butyldiphenylsilyloxy)butanoate

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 48h;
87%
(S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester
59768-74-0,124184-67-4

(S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 1.) N-hydroxysuccinimide, DCC; 2.) NaBH4 / 1.) CH2Cl2, r.t., 3 h; 2.) THF, EtOH, 0 deg C, 15 min
2: p-TsOH / CH2Cl2 / Ambient temperature
With sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In dichloromethane;
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h
1.2: 0.5 h
2.1: boron trifluoride diethyl etherate / acetone / 4 h / 20 °C
With 4-methyl-morpholine; boron trifluoride diethyl etherate; chloroformic acid ethyl ester; In tetrahydrofuran; acetone;
Multi-step reaction with 2 steps
1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / Cooling with ice
2: boron trifluoride diethyl etherate / acetone / 4 h / 20 °C
With 4-methyl-morpholine; boron trifluoride diethyl etherate; chloroformic acid ethyl ester; In tetrahydrofuran; acetone;
di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 95 percent / 0.5M aq.Na2CO3 / dioxane / Ambient temperature
2: 1.) N-hydroxysuccinimide, DCC; 2.) NaBH4 / 1.) CH2Cl2, r.t., 3 h; 2.) THF, EtOH, 0 deg C, 15 min
3: p-TsOH / CH2Cl2 / Ambient temperature
With sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; sodium carbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester
136703-59-8

(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
With toluene-4-sulfonic acid; In dichloromethane; Yield given; Ambient temperature;
With boron trifluoride diethyl etherate; In acetone; at 20 ℃; for 4h;
8.72 g
methyl (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxybutanoate
1062238-49-6

methyl (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxybutanoate

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
With boron trifluoride diethyl etherate; In acetone; at 20 ℃; for 4h;
8.72 g
methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-(tert-butyldiphenylsilyloxy)butanoate
869212-63-5

methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-(tert-butyldiphenylsilyloxy)butanoate

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 48h;
87%
(S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester
59768-74-0,124184-67-4

(S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 1.) N-hydroxysuccinimide, DCC; 2.) NaBH4 / 1.) CH2Cl2, r.t., 3 h; 2.) THF, EtOH, 0 deg C, 15 min
2: p-TsOH / CH2Cl2 / Ambient temperature
With sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In dichloromethane;
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h
1.2: 0.5 h
2.1: boron trifluoride diethyl etherate / acetone / 4 h / 20 °C
With 4-methyl-morpholine; boron trifluoride diethyl etherate; chloroformic acid ethyl ester; In tetrahydrofuran; acetone;
Multi-step reaction with 2 steps
1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / Cooling with ice
2: boron trifluoride diethyl etherate / acetone / 4 h / 20 °C
With 4-methyl-morpholine; boron trifluoride diethyl etherate; chloroformic acid ethyl ester; In tetrahydrofuran; acetone;
di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate
205491-14-1

methyl [(4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]ethanoate

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 95 percent / 0.5M aq.Na2CO3 / dioxane / Ambient temperature
2: 1.) N-hydroxysuccinimide, DCC; 2.) NaBH4 / 1.) CH2Cl2, r.t., 3 h; 2.) THF, EtOH, 0 deg C, 15 min
3: p-TsOH / CH2Cl2 / Ambient temperature
With sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; sodium carbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;

Global suppliers and manufacturers

Global( 1) Suppliers
  • Company Name
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  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
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