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All total 4 Articles be found
Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles
Ratcliffe, Paul,Abernethy, Lynn,Ansari, Nasrin,Cameron, Ken,Clarkson, Tom,Dempster, Maureen,Dunn, David,Easson, Anna-Marie,Edwards, Darren,Everett, Katy,Feilden, Helen,Ho, Koc-Kan,Kultgen, Steve,Littlewood, Peter,MacLean, John,McArthur, Duncan,McGregor, Deborah,McLuskey, Hazel,Neagu, Irina,Nimz, Olaf,Nisbet, Lesley-Anne,Ohlmeyer, Michael,Palin, Ronnie,Pham, Quynhchi,Rong, Yajing,Roughton, Andrew,Sammons, Melanie,Swanson, Robert,Tracey, Heather,Walker, Glenn
, p. 4652 - 4657 (2011/09/12)
Systematic optimisation of a poorly soluble lead series of isoxazole-3-carboxamides was conducted. Substitution of the 4-position with specific polar functionality afforded the requisite balance of potency, solubility and physicochemical properties. Compo
Concise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins
Wang, Xi-Zhao,Jia, Jiong,Zhang, Yan,Xu, Wei-Ren,Liu, Wei,Shi, Fang-Niu,Wang, Jian-Wu
, p. 643 - 652 (2008/03/11)
The synthesis of a series of new 5-isoxazolpenicillins is described, which were obtained by coupling substituted isoxazoles with 6-APA. Concise large-scale synthesis of 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition using copper(I) as catalyst was also investigated. Representative compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-negative bacteria.