Welcome to LookChem.com Sign In|Join Free

Cas Database

206055-88-1

206055-88-1

Identification

Synonyms:3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

Post Buying Request Now

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase

Relevant articles and documentsAll total 4 Articles be found

Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles

Ratcliffe, Paul,Abernethy, Lynn,Ansari, Nasrin,Cameron, Ken,Clarkson, Tom,Dempster, Maureen,Dunn, David,Easson, Anna-Marie,Edwards, Darren,Everett, Katy,Feilden, Helen,Ho, Koc-Kan,Kultgen, Steve,Littlewood, Peter,MacLean, John,McArthur, Duncan,McGregor, Deborah,McLuskey, Hazel,Neagu, Irina,Nimz, Olaf,Nisbet, Lesley-Anne,Ohlmeyer, Michael,Palin, Ronnie,Pham, Quynhchi,Rong, Yajing,Roughton, Andrew,Sammons, Melanie,Swanson, Robert,Tracey, Heather,Walker, Glenn

, p. 4652 - 4657 (2011/09/12)

Systematic optimisation of a poorly soluble lead series of isoxazole-3-carboxamides was conducted. Substitution of the 4-position with specific polar functionality afforded the requisite balance of potency, solubility and physicochemical properties. Compo

Concise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins

Wang, Xi-Zhao,Jia, Jiong,Zhang, Yan,Xu, Wei-Ren,Liu, Wei,Shi, Fang-Niu,Wang, Jian-Wu

, p. 643 - 652 (2008/03/11)

The synthesis of a series of new 5-isoxazolpenicillins is described, which were obtained by coupling substituted isoxazoles with 6-APA. Concise large-scale synthesis of 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition using copper(I) as catalyst was also investigated. Representative compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-negative bacteria.

Process route upstream and downstream products

Process route

N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride
74467-05-3

N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride

propargyl alcohol
107-19-7

propargyl alcohol

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

Conditions
Conditions Yield
With potassium hydrogencarbonate; copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 1.5h;
71%
With triethylamine; In toluene; at 20 ℃;
With triethylamine; In toluene; at 25 ℃;
propargyl alcohol
107-19-7

propargyl alcohol

(Z)-N-hydroxy-4-(trifluoromethyl)benzimidoyl chloride

(Z)-N-hydroxy-4-(trifluoromethyl)benzimidoyl chloride

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

Conditions
Conditions Yield
With triethylamine; In dichloromethane; at 0 - 20 ℃; Yield given;
4-(trifluoromethyl)benzaldehyde oxime
66046-34-2

4-(trifluoromethyl)benzaldehyde oxime

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: N-chlorosuccinimide / dimethylformamide / Ambient temperature
2: Et3N / CH2Cl2 / 0 - 20 °C
With N-chloro-succinimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 2 steps
1: N-chloro-succinimide / N,N-dimethyl-formamide / 25 °C
2: triethylamine / toluene / 25 °C
With N-chloro-succinimide; triethylamine; In N,N-dimethyl-formamide; toluene;
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; potassium hydroxide / ethanol; water / 25 °C
2: N-chloro-succinimide / N,N-dimethyl-formamide / 25 °C
3: triethylamine / toluene / 25 °C
With N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene;
3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

3-(4-(trifluoromethyl)phenyl)isoxazole-5-carbaldehyde

3-(4-(trifluoromethyl)phenyl)isoxazole-5-carbaldehyde

Conditions
Conditions Yield
With Jones reagent; In acetone; at 0 ℃; for 0.583333h;
68%
1,1'-bisferrocenedicarboxylic acid

1,1'-bisferrocenedicarboxylic acid

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

C<sub>34</sub>H<sub>22</sub>F<sub>6</sub>FeN<sub>2</sub>O<sub>6</sub>

C34H22F6FeN2O6

Conditions
Conditions Yield
1,1'-bisferrocenedicarboxylic acid; With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere; Cooling;
With dmap; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere; Cooling;
3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
68%
acetic acid
64-19-7,77671-22-8

acetic acid

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

(4-chloro-3-(4-(trifluoromethyl)phenyl)isoxazol-5-yl)methyl acetate
1239576-19-2

(4-chloro-3-(4-(trifluoromethyl)phenyl)isoxazol-5-yl)methyl acetate

Conditions
Conditions Yield
acetic acid; 3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole; With N-chloro-succinimide; sulfuric acid; at 120 ℃; for 5h;
With sodium carbonate; In water; ethyl acetate;
With N-chloro-succinimide; sulfuric acid; at 120 ℃;
acetic acid
64-19-7,77671-22-8

acetic acid

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

(4-bromo-3-(4-(trifluoromethyl)phenyl)isoxazol-5-yl)methyl acetate
1239576-21-6

(4-bromo-3-(4-(trifluoromethyl)phenyl)isoxazol-5-yl)methyl acetate

Conditions
Conditions Yield
acetic acid; 3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole; With N-Bromosuccinimide; sulfuric acid; at 120 ℃; for 5h;
With sodium carbonate; In water; ethyl acetate;
3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid

3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid

Conditions
Conditions Yield
With jones reagent; In acetone; at 0 - 35 ℃; for 3.5h;
95%
3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole
206055-88-1

3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazole

4-chloro-3-(4-(trifluoromethyl)phenyl)isoxazole-5-carboxylic acid
1239576-18-1

4-chloro-3-(4-(trifluoromethyl)phenyl)isoxazole-5-carboxylic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: N-chloro-succinimide; sulfuric acid / 120 °C
2.1: methanol; lithium hydroxide / tetrahydrofuran; water / 60 °C
3.1: sodium dihydrogenphosphate; sodium chlorite; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; acetonitrile / 35 °C
3.2: 25 °C
With methanol; sodium hypochlorite; sodium chlorite; sodium dihydrogenphosphate; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sulfuric acid; lithium hydroxide; In tetrahydrofuran; water; acetonitrile;

Global suppliers and manufacturers

Global( 0) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 206055-88-1
Post Buying Request Now
close
Remarks: The blank with*must be completed