20725-32-0

Basic information

• Product Name: 5-Methyl-1-phenyl-1H-[1, 2, 3]triazole-4-carboxylic acid
• Synonyms: 5-Methyl-1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid;5-methyl-1-phenyl-1,2,3-triazole-4-carboxylic acid;5-methyl-1-phenyl-4-triazolecarboxylic acid;5-methyl-1-phenyl-triazole-4-carboxylic acid;5-methyl-1-phenyltriazole-4-carboxylic acid
• CAS NO: 20725-32-0
• Molecular Formula: C₁₀H₉N₃O₂
• Molecular Weight: 203.2
• Mol File: 20725-32-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 432.9 °C at 760 mmHg
• Flash Point: 215.6 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 2.91E-08mmHg at 25°C
• Refractive Index: 1.653
• PKA: pK1:3.73 (25°C)
• CAS DataBase Reference: 5-Methyl-1-phenyl-1H-[1, 2, 3]triazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-1-phenyl-1H-[1, 2, 3]triazole-4-carboxylic acid(20725-32-0)
• EPA Substance Registry System: 5-Methyl-1-phenyl-1H-[1, 2, 3]triazole-4-carboxylic acid(20725-32-0)

Safety Data

• Hazardous Substances Data: 20725-32-0(Hazardous Substances Data)

Usage

General Description

5-Methyl-1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid is a chemical compound with the molecular formula C10H8N4O2. It is a triazole derivative, which is a type of heterocyclic compound containing three nitrogen atoms in the ring structure. 5-Methyl-1-phenyl-1H-[1, 2, 3]triazole-4-carboxylic acid is often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and materials science. It has potential applications in the field of medicinal chemistry and is being studied for its potential antifungal, antibacterial, and anticancer properties. 5-Methyl-1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid is a versatile building block that can be modified to create a variety of derivatives with different chemical and biological properties.

InChI:InChI=1/C10H9N3O2/c1-7-9(10(14)15)11-12-13(7)8-5-3-2-4-6-8/h2-6H,1H3,(H,14,15)

Upstream product

• 1118-61-2 3-Aminocrotononitrile 
• 622-37-7 Phenyl azide 
• 27049-64-5 5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxylic acid ethyl ester 
• 13148-05-5 ethyl 3-oxo-4-(triphenylphosphoranylidene)butanoate 
• 64-17-5 ethanol 
• 62-53-3 aniline 
• 100-63-0 phenylhydrazine 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 923679-02-1 N-(5-benzyl-1,3-thiazol-2-yl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 871323-26-1 5-methyl-1-phenyl-N-(4-sulfamoylphenyl)-1H-1,2,3-triazole-4-carboxamide 

Relevant articles and documents

Homocoupling of bromotriazole derivatives on metal complex catalysts

Homocoupling of 4-bromo-1,2,3-triazoles upon treatment with stoichiometric amount of bis(pinacolato)diboron on a palladium catalyst gives 4,4-bi-1,2,3-triazoles in up to 95% yields.

Primary discovery of 1-aryl-5-substituted-1H-1,2,3-triazole-4-carboxamides as promising antimicrobial agents

Three series of novel 1H-1,2,3-triazole-4-carboxamides: 1-aryl-5-alkyl/aryl-1H-1,2,3-triazole-4-carboxamides, 1-aryl-5-amino-1H-1,2,3-triazole-4-carboxamides and 1,2,3-triazolo[1,5-a]quinazoline-3-carboxamides were synthesized via base-mediated click azide reactions. Compounds were evaluated for their antimicrobial activities against primary pathogens: Gram-positive and Gram-negative bacterial strains Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, as well as fungal strain Cryptococcus neoformans var. grubii and Candida albicans. Compounds exhibiting moderate to good activities were selected for SAR analysis. Several 5-methyl-1H-1,2,3-triazole-4-carboxamides 4d, 4l, 4r, showed potent antibacterial effect against S. aureus. On the contrary, 5-amino-1H-1,2,3-triazole-4-carboxamide 8b and [1,2,3]triazolo[1,5-a]quinazoline-3-carboxamide 9a were active against pathogenic yeast C. albicans. Thus, compound 4l under 1 μM demonstrated 50% growth inhibition against S. aureus. At the same concentration, the compound 9a killed approx. 40% of C. albicans cells. In general, these compounds demonstrated selective action and no significant impact on the viability of human keratinocytes of HaCaT line.

Picolinamide compound containing triazole or quinolinone structure and application of picolinamide compound

The invention provides a picolinamide compound containing a triazole or quinolinone structure and application of the picolinamide compound. According to a technical scheme in the invention, extensiveresearch is conducted on the picolinamide compound, and

Design, synthesis and anticancer activity evaluation of aziridine-1,2,3-triazole hybrid derivatives

New 1-aryl-4-[(aziridine-1-yl)diarylmethyl]-5-methyl-1H-1,2,3-triazole derivatives 7a-i were synthesized by a one-pot reaction of diaryl-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)methanols 6a-i derived from 1-aryl-5-methyl-1H-1,2,3-triazole-4-carboxylic acid