20877-81-0

Basic information

• Product Name: 6-Methylisatoic anhydride
• Synonyms: 5-methyl-2H-3,1-benzoxazin-2,4(1H)-dione;5-methyl-1H-3,1-benzoxazine-2,4-dione
• CAS NO: 20877-81-0
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.15678
• Mol File: 20877-81-0.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Methylisatoic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methylisatoic anhydride(20877-81-0)
• EPA Substance Registry System: 6-Methylisatoic anhydride(20877-81-0)

Safety Data

• Hazardous Substances Data: 20877-81-0(Hazardous Substances Data)

Upstream product

• 269391-47-1 2-{((1,1-Dimethylethoxy)carbonyl]amino)-6-methylbenzoic acid 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 503-38-8 trichloromethyl chloroformate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 75-44-5 phosgene 
• 1128-44-5 4-methyl-1H-indole-2,3-dione 

Downstream Products

• 20878-64-2 3-Methyl-2-(3,4,5-trimethoxy-phenylcarbamoyl)-anilin 
• 153501-37-2 ethyl N-[2-(ethoxycarbonyl)-3-methylphenyl]glycinate 
• 686265-99-6 1-benzyl-(4-methyl)benzo[2,3-d][1,3]oxazine-2,4-dione 
• 1337543-02-8 ethyl 4-(4-methoxybenzylamino)-2,5-dimethylquinoline-3-carboxylate 
• 1464831-41-1 2-(2-bromophenyl)-5-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one 
• 1464831-55-7 8-methyl-5-phenylindazolo[3,2-b]quinazolin-7(5H)-one 
• 1383427-53-9 ingenol-5,20-acetonide-3-(2-amino-6-methyl-benzoate) 
• 1383427-55-1 ingenol-5,20-acetonide-3-(2-methyl-6-methylamino-benzoate) 

Relevant articles and documents

Synthesis of novel quinoxaline-5-carboxylic acid derivatives

This paper describes the synthesis of several new 2,3-dimethoxy-6- methyl-7-nitro-quinoxaline-5-carboxylic acid derivatives (13a-m) via a multistep synthetic route from 5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione (1).

Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using p Ka-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam

An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam 3, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.

NOVEL PIPERIDINE-2,6-DIONE DERIVATIVE AND USE THEREOF

The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.