686265-99-6Relevant academic research and scientific papers
A practical method for preparation of 4-hydroxyquinolinone esters
Beutner, Gregory L.,Kuethe, Jeffrey T.,Yasuda, Nobuyoshi
, p. 7058 - 7061 (2007)
(Chemical Equation Presented) 4-Hydroxyquinolinone esters are a common motif for many medicinal agents. Several methods exist for preparation of these compounds, generally involving the use of sodium hydride, which raises significant safety issues and limits their application to large-scale synthesis. In this note a practical, safe, and general method that employs a combination of diisopropylethylamine and sodium tert-butoxide is described. This allows for the synthesis of 4-hydroxyquinolinone esters and amides in good yields.
Anti-infective agents
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Page 65-66, (2010/02/06)
Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
Anti-infective agents
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, (2008/06/13)
Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
