21339-47-9

Basic information

• Product Name: 3,3-DIETHOXYPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER
• Synonyms: DIETHYL 3,3-DIETHOXYPROPANE-1,1-DICARBOXYLATE;3,3-DIETHOXYPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER;Diethoxypropanedicarboxylicaciddiethylester;Propanedioic acid, 2-(2,2-diethoxyethyl)-, 1,3-diethyl ester;Diethyl 2-(2,2-diethoxyethyl)malonate
• CAS NO: 21339-47-9
• Molecular Formula: C₁₃H₂₄O₆
• Molecular Weight: 276.33
• Mol File: 21339-47-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 331.4 °C at 760 mmHg
• Flash Point: 140.7 °C
• Appearance: /
• Density: 1.048 g/cm³
• Vapor Pressure: 0.000157mmHg at 25°C
• Refractive Index: 1.4270 to 1.4290
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.75±0.59(Predicted)
• CAS DataBase Reference: 3,3-DIETHOXYPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DIETHOXYPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER(21339-47-9)
• EPA Substance Registry System: 3,3-DIETHOXYPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER(21339-47-9)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 21339-47-9(Hazardous Substances Data)

Usage

General Description

3,3-Diethoxypropane-1,1-dicarboxylic acid diethyl ester is a chemical compound that is commonly used as a crosslinking agent in the production of thermosetting resins. It is an ester of diethyl malonate and is known for its ability to efficiently crosslink with other compounds, making it a valuable component in the manufacture of polymers, adhesives, and coatings. This chemical is also used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a versatile and important chemical in the fields of materials science, pharmaceuticals, and agriculture.

InChI:InChI=1/C13H24O6/c1-5-16-11(17-6-2)9-10(12(14)18-7-3)13(15)19-8-4/h10-11H,5-9H2,1-4H3

Upstream product

• 996-82-7 sodium diethylmalonate 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 1634-04-4 tert-butyl methyl ether 
• 105-53-3 diethyl malonate 

Downstream Products

• 1149618-40-5 2-(2,2-diethoxy-ethyl)-2-(3-phenyl-prop-2-ynyl)malonic acid diethyl ester 
• 1254985-01-7 2-(2,2-diethoxyethyl)-2-(5-phenylpent-4-ynyl)malonic acid diethyl ester 
• 333335-50-5 benzoic acid 5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-ylmethyl ester 
• 333335-54-9 benzoic acid 5-(2-amino-6-chloro-purin-9-yl)-tetrahydro-furan-3-ylmethyl ester 
• 333335-49-2 2-acetoxy-4-benzoyloxymethylterahydrofuran 
• 333335-47-0 benzoic acid 5-ethoxy-tetrahydro-furan-3-ylmethyl ester 
• 333335-48-1 benzoic acid 5-hydroxy-tetrahydro-furan-3-ylmethyl ester 
• 172529-94-1 2-amino-6-chloro-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine 
• 39809-25-1 Penciclovir 
• 97845-60-8 9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-chloro-9H-purine 
• 104227-87-4 9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine 
• 84583-33-5 2-<2,2-Bis(ethoxycarbonyl)-4,4-diethoxy-1-butyl>-3-<(phenylsulfonyl)methyl>pyridine 
• 84583-36-8 2-<(Phenylsulfonyl)methyl>-3-<2,2-bis(ethoxycarbonyl)-4,4-diethoxy-1-butyl>pyridine 
• 88116-05-6 4-Benzenesulfonyl-2-(2,2-diethoxy-ethyl)-3-oxo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester 

Relevant articles and documents

Samarium Diiodide Catalyzed Radical Cascade Cyclizations that Construct Quaternary Stereocenters

SmI 2 -catalyzed radical cascade cyclizations were used to generate complex carbocyclic products bearing quaternary stereocenters with high selectivity. Bicyclic scaffolds containing four contiguous stereocenters and one quaternary stereocenter

Four nucleophilic additions to alkenynedioic acid derivatives in tandem; Efficient one-pot synthesis of bicyclo[4.2.0]octenols

When alkenynedioic acid derivatives were treated with a Grignard reagent, tandem cyclization and the incorporation of two molecules of the Grignard reagent occurred to give stereodefined bicyclo[4.2.0]octenols via four nucleophilic additions.

Regioselective alkylation of guanines using 2-acetoxytetrahydrofurans

Reaction of silylated guanine derivatives with 2-acetoxy-4-benzoyloxymethyltetrahydrofuran in DMF or NMP resulted in selective N-9 alkylation. This was used as the basis for a regioselective synthesis of the anti-viral agents famciclovir and penciclovir.