333335-54-9

Upstream product

• 10310-21-1 2-Amino-6-chloropurin 
• 333335-49-2 2-acetoxy-4-benzoyloxymethylterahydrofuran 
• 55387-85-4 3-hydroxymethyl-4-hydroxybutanal diethyl acetal 
• 21339-47-9 diethyl 2-(2,2-diethoxyethyl)malonate 
• 333335-46-9 (5-ethoxy-tetrahydro-furan-3-yl)-methanol 
• 333335-48-1 benzoic acid 5-hydroxy-tetrahydro-furan-3-ylmethyl ester 
• 333335-47-0 benzoic acid 5-ethoxy-tetrahydro-furan-3-ylmethyl ester 

Downstream Products

• 172529-94-1 2-amino-6-chloro-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine 
• 97845-60-8 9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-chloro-9H-purine 
• 104227-87-4 9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine 

Relevant academic research and scientific papers

Regioselective alkylation of guanines using 2-acetoxytetrahydrofurans

Reaction of silylated guanine derivatives with 2-acetoxy-4-benzoyloxymethyltetrahydrofuran in DMF or NMP resulted in selective N-9 alkylation. This was used as the basis for a regioselective synthesis of the anti-viral agents famciclovir and penciclovir.