218632-36-1Relevant articles and documents
PYRAZOLOPYRIDAZINE DERIVATIVES, PREPARATION METHOD THEREOF AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME
-
Paragraph 0203-0204; 0209-0212, (2020/11/14)
The present invention is a pyrazolopyridazine derivative. A pharmaceutical composition for preventing or treating cancer contains the pyrazolopyridazin derivative compound Hsp90 according to the present invention as an active ingredient, which can be used as Hsp90 a pharmaceutical composition for preventing or treating Hsp90-related diseases such as melanoma, brain tumor, breast cancer, lung cancer and the like. (by machine translation)
Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors
Kishk, Safaa M.,McLean, Kirsty J.,Sood, Sakshi,Smith, Darren,Evans, Jack W.D.,Helal, Mohamed A.,Gomaa, Mohamed S.,Salama, Ismail,Mostafa, Samia M.,de Carvalho, Luiz Pedro S.,Levy, Colin W.,Munro, Andrew W.,Simons, Claire
, p. 995 - 1011 (2019/08/06)
The emergence of untreatable drug-resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. Mycobacterium tuberculosis cytochrome P450 CYP121A1 is a p
Microwave-assisted synthesis of tetrazolyl pyrazole amides
Hu, Jun,Wang, Jikui,Zhou, Taoyu,Xu, Yanhua
experimental part, p. 525 - 527 (2011/11/30)
A rapid and efficient microwave-assisted synthesis N-(1H-tetrazol-5-yl) derivatives of 3-methyl-1-phenyl-1H-pyrazole- 5-carboxamide is described. These tetrazole pyrazole amides have interesting bacteriocidal, pesticidal, herbicidal and antimicrobial activities. They were identified by IR and 1H NMR elemental analyses. The target compounds were obtained in a shorter reaction time compared to conventional heating methods.
Pyrazoles for the treatment of obesity and other CNS disorders
-
Page/Page column 14; 15; 26; 27, (2010/11/28)
This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain pyrazole derivatives, their salts and solvates. These compounds have H3 histamine receptor binding activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H3 receptor modulation is beneficial.
Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2′ -(aminosulfonyl)[1,1′-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor
Pruitt, James R.,Pinto, Donald J. P.,Galemmo Jr., Robert A.,Alexander, Richard S.,Rossi, Karen A.,Wells, Brian L.,Drummond, Spencer,Bostrom, Lori L.,Burdick, Debra,Bruckner, Robert,Chen, Haiying,Smallwood, Angela,Wong, Pancras C.,Wright, Matthew R.,Bai, Steven,Luettgen, Joseph M.,Knabb, Robert M.,Lam, Patrick Y. S.,Wexler, Ruth R.
, p. 5298 - 5315 (2007/10/03)
Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide effective treatment for both venous and arterial thrombosis. We recentl