219821-37-1 Usage
Description
2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester is a complex organic compound characterized by its intricate molecular structure. It features a hydrazinecarboxylic acid methyl ester group along with various functional groups such as trifluoromethyl, phenyl, ethoxy, fluorophenyl, and morpholinyl. The presence of these diverse groups suggests that the compound may exhibit a broad spectrum of chemical and biological properties, making it a candidate for various applications in fields such as pharmaceuticals, agrochemicals, and materials science.
Uses
Used in Pharmaceutical Industry:
2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester is used as a pharmaceutical agent for its potential therapeutic effects. 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester's unique structure and functional groups may contribute to its ability to interact with biological targets, such as enzymes or receptors, and modulate their activity, leading to potential applications in the treatment of various diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester may be utilized as an active ingredient in pesticides or herbicides. Its chemical properties and functional groups could enable it to target specific pests or weeds, providing an effective and selective control method.
Used in Materials Science:
2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester can be employed in materials science for the development of novel materials with specific properties. 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester's structural features may allow it to be incorporated into polymers, coatings, or other materials, imparting unique characteristics such as enhanced stability, reactivity, or selectivity in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 219821-37-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,8,2 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 219821-37:
(8*2)+(7*1)+(6*9)+(5*8)+(4*2)+(3*1)+(2*3)+(1*7)=141
141 % 10 = 1
So 219821-37-1 is a valid CAS Registry Number.
219821-37-1Relevant articles and documents
Method for preparing intermediate of the Fosaprepitant
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Paragraph 0017; 0030-0039, (2018/05/16)
The invention discloses a method for preparing an intermediate of the Fosaprepitant, and specifically relates to a new method for preparing a drug 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one, i.e., Aprepitant. The method comprises the steps of: synthesizing a compound (IV) in the presence of a condensation system, and then performing cyclization on the compound (IV) at 139 DEG C or below to obtain the target compound (I). The preparation method is green, environmentally friendly and efficient and has easy industrialization.
A kind of preparation method of dimethyl luck Sha Pitan cyclophosphadenosine
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Paragraph 0042-0044, (2017/04/07)
The invention relates to a method for preparing fosaprepitant. The fosaprepitant is shown as a formula (I). The method comprises steps 1, 2, 3 and 4, finally, a compound shown as the formula (I) is obtained through hydrogenation reduction; in the step 1, a compound in a formula (II) reacts with a Grignard reagent to generate a compound shown as a formula (III) in the presence of palladium carbon and ammonium formate. The method for preparing is simple in production step, has high reaction yield and less side products, is easy in control of the reaction conditions and is suitable for medical industrial production.
A METHOD OF PREPARING 3- ( ( (2R, 3S) -2- ( (R) -1- (3, 5 -BIS (TRIFLUOROMETHYL) PHENYL) ETHOXY) -3 - (4 - FLUOROPHENYL) MORPHOLINO) METHYL) - 1H- 1, 2, 4 -TRIAZOL- 5 (4H) -ONE (APREPITANT) IN POLYMORPH FORM I OR II
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Page/Page column 6; 7, (2013/09/26)
The present solution relates to a method of preparing aprepitant of formula (1) in the desired crystalline form II or I, wherein the intermediate of formula (12) is extracted with a water immiscible high-boiling solvent selected from an alcohol, ester or ketone and, after washing with water and/or brine, the solution is heated up to the boiling point of the given solvent, which results in cyclization to aprepitant, and, after cooling, the produced aprepitant is isolated.
