110843-90-8

Basic information

• Product Name: 4-Benzyl-2,3-Morpholinedione
• Synonyms: 4-Benzyl-2,3-Morpholinedione;4-benzylmorpholine-2,3-dione(WXC03066)
• CAS NO: 110843-90-8
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.20994
• Mol File: 110843-90-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Benzyl-2,3-Morpholinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzyl-2,3-Morpholinedione(110843-90-8)
• EPA Substance Registry System: 4-Benzyl-2,3-Morpholinedione(110843-90-8)

Safety Data

• Hazardous Substances Data: 110843-90-8(Hazardous Substances Data)

Usage

Uses

4-Benzyl-2,3-morpholinedione, is an intermediate used in the synthesis of NK1 Receptor Antagonist Aprepitant (A729800), used as as antiemetic drug.

Upstream product

• 10316-00-4 4-benzyl-morpholine 
• 95-92-1 oxalic acid diethyl ester 
• 104-63-2 N-Benzylethanolamine 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1360057-98-2 4-benzyl-2-(3,4-dichlorophenyl)-2-hydroxy-morpholin-3-one 
• 1360058-00-9 4-benzyl-2-(3,4-dichlorophenyl)-morpholin-3-one 
• 1360058-02-1 C₂₀H₂₁Cl₂NO 
• 1360058-04-3 4-benzyl-2-[(3,4-dichloro-phenyl)-morpholin-2-yl]-acetaldehyde 
• 1360057-99-3 4-benzyl-2-(3,4-dichlorophenyl)-2-methoxy-morpholin-3-one 
• 1446355-98-1 4-benzyl-2-(3,4-difluorophenyl)-2-hydroxy-morpholin-3-one 
• 1446355-97-0 4-benzyl-2-phenyl-2-hydroxy-morpholin-3-one 
• 1446356-02-0 4-benzyl-2-(3,4-difluorophenyl)-morpholin-3-one 
• 1446356-01-9 4-benzyl-2-phenyl-morpholin-3-one 
• 1446356-00-8 4-benzyl-2-(3,4-difluorophenyl)-2-methoxy-morpholin-3-one 
• 1446355-99-2 4-benzyl-2-phenyl-2-methoxy-morpholin-3-one 
• 1446356-07-5 2-allyl-4-benzyl-2-(3,4-difluoro-phenyl)-morpholin-3-one 
• 1446356-06-4 2-allyl-4-benzyl-2-phenyl-morpholin-3-one 
• 219821-37-1 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-4-fluorophenyl-4-2-(N-methylcarboxyactamidrazono)morpholine 

Relevant articles and documents

Palladium-catalysed Cross Double Carbonylation of Amines and Alcohols: Synthesis of Oxamates

Cross double carbonylation of amines and alcohols in the presence of PdCl2(MeCN)2/CuI catalyst under CO and O2 at room temperature gives oxamates efficiently.

PIDA/I2-Mediated α- And β-C(sp3)-H Bond Dual Functionalization of Tertiary Amines

The α,β-C(sp3)-H bond dual functionalization of tertiary amines is still a challenging task for both organic and medicinal chemists. Herein a direct, mild, metal-free, and site-specific method mediated by PIDA/I2 was developed for α,

Synthesis of a chiral key intermediate of neurokinin antagonist SSR 240600 by asymmetric allylic alkylation

The preparation of optically active morpholine-2-aryl-2-acetaldehyde from morpholine-2-aryl-3-one is reported. The quaternary carbon is introduced during a palladium-promoted asymmetric allylic alkylation. This is a useful intermediate in the synthesis an