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2215-54-5

5-Chloro-1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one is a chemical compound with the molecular formula C15H12ClNO. It is a derivative of benzimidazolone, featuring a chlorine atom at the 5th position, a phenylmethyl group attached to the 1st position, and a hydrogen atom at the 3rd position. 5-Chloro-1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one is known for its potential applications in pharmaceuticals and as a building block in the synthesis of various organic compounds. It is characterized by its white crystalline appearance and is typically used in research and development settings due to its unique chemical properties and reactivity.

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  • 2215-54-5 Structure

  • Basic information

    1. Product Name: 5-Chloro-1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one
    2. Synonyms: 5-Chloro-1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one
    3. CAS NO:2215-54-5
    4. Molecular Formula: C14H11ClN2O
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2215-54-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-Chloro-1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-Chloro-1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one(2215-54-5)
    11. EPA Substance Registry System: 5-Chloro-1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one(2215-54-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2215-54-5(Hazardous Substances Data)

2215-54-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2215-54-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,1 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2215-54:
(6*2)+(5*2)+(4*1)+(3*5)+(2*5)+(1*4)=55
55 % 10 = 5
So 2215-54-5 is a valid CAS Registry Number.

2215-54-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-benzyl-5-chloro-1H-benzo[d]imidazol-2(3H)-one

1.2 Other means of identification

Product number -
Other names 1-Benzyl-5-chloro-1,3-dihydro-benzoimidazol-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2215-54-5 SDS

2215-54-5Relevant articles and documents

Novel benzo[d]imidazole-2(3H)-thiones as potent inhibitors of the α-melanocyte stimulating hormone induced melanogenesis in melanoma B16 cells

Lee, Jee-Hyun,Thanigaimalai, Pillaiyar,Lee, Ki-Cheul,Bang, Seong-Cheol,Kim, Min-Seok,Sharma, Vinay Kumar,Yun, Cheong-Yong,Roh, Eunmiri,Kim, Youngsoo,Jung, Sang-Hun

experimental part, p. 918 - 921 (2010/09/04)

In order to determine the optimum size of heterocycle of lead compound 1 (6-methyl-3-phenethyl-3,4-dihydro-1H-quinoline-2-thione; IC50=0.8 μM) for inhibition of melanogenesis, we have synthesized and evaluated some benzimdazole-2(3H)-thiones 5a

New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation

Orjales, Aurelio,Mosquera, Ramón,Labeaga, Luis,Rodes, Rosa

, p. 586 - 593 (2007/10/03)

A series of 2-piperazinylbenzimidazole derivatives were prepared and evaluated as 5-HT3 receptor antagonists. Their 5-HT3 receptor affinities were evaluated by radioligand binding assays, and their abilities to inhibit the 5-HT-induced Bezold-Jarisch reflex in anesthetized rats were determined. Compound 7e (lerisetron, pK(i) = 9.2) exhibited higher affinity for the 5- HT3 receptor than did tropisetron and granisetron, while compound 7q (pK(i) = 7.5) had very low affinity for this receptor, showing that substitution on the N1 atom of the benzimidazole ring is essential for affinity and activity. The effect of substitution on the aromatic ring of benzimidazole by several substituents in different positions is also discussed. A strong correlation between the 5-HT3 antagonistic activity of the studied compounds and the position of substitution on the aromatic ring was established. Thus, while the 4-methoxy derivative 7m showed weak affinity for the 5-HT3 receptor (pK(i) = 6.7), the 7-methoxy derivative 7n exhibited the highest affinity (pK(i) = 9.4). Compounds 7e and 7n are now under further investigation as drugs for the treatment of nausea and emesis evoked by cancer chemotherapy and radiation.

Regiospecific functionalization of 1,3-dihydro-2H-benzimidazol-2-one and structurally related cyclic urea derivatives

Meanwell,Sit,Gao,Wong,Gao,St. Laurent,Balasubramanian

, p. 1565 - 1582 (2007/10/02)

Methods for selectively protecting one of the degenerate nitrogen atoms of the cyclic urea derivatives 1,3-dihydro-2H-benzimidazol-2-one (6a), 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (11), 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones (20), 1,3-dihydro-

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