22849-49-6 Usage
Uses
Used in Pharmaceutical Research:
H-GLY-ALA-LEU-OH is utilized as a research compound for exploring its biochemical properties and potential therapeutic applications. Its specific sequence may offer insights into peptide-based drug development and the understanding of protein interactions.
Used in Protein Synthesis:
In the field of biochemistry, H-GLY-ALA-LEU-OH is employed as a component in protein synthesis studies, aiding in the investigation of amino acid chain assembly and the role of specific sequences in protein function and structure.
Used in Scientific Studies:
H-GLY-ALA-LEU-OH is applied as a model peptide in various scientific studies to examine its biological effects, interactions with other molecules, and its potential use in the development of novel therapeutic agents or diagnostic tools.
Used in Peptide Drug Development:
In the pharmaceutical industry, H-GLY-ALA-LEU-OH is used as a building block in the design and synthesis of peptide-based drugs, leveraging its specific properties to target particular biological pathways or receptors.
Used in Cosmetics and Personal Care:
H-GLY-ALA-LEU-OH may also find application in the cosmetics and personal care industry, potentially serving as an active ingredient to promote skin health or as a component in formulations that enhance product efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 22849-49-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,8,4 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 22849-49:
(7*2)+(6*2)+(5*8)+(4*4)+(3*9)+(2*4)+(1*9)=126
126 % 10 = 6
So 22849-49-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H21N3O4/c1-6(2)4-8(11(17)18)14-10(16)7(3)13-9(15)5-12/h6-8H,4-5,12H2,1-3H3,(H,13,15)(H,14,16)(H,17,18)
22849-49-6Relevant articles and documents
2,2'-Spirobi(1,3,2-benzodioxaphosphole): an Inexpensive and Effective Reagent for Peptide Synthesis
Cadogan, J. I. G.,Gosney, Ian,Randles, David,Yaslak, Salih,Ambler, Richard P.
, p. 298 - 299 (1982)
The readily accessible spirocyclic oxyphosphorane, 2,2'-spirobi(1,3,2-benzodioxaphosphole) (1), is a convenient and effective reagent for peptide coupling, racemisation as measured by the Izumiya test being strikingly suppressed 0.1percent in the presence of N-hydroxysuccinimide.
Effect of solvent on racemization in carbodiimide mediated solid phase fragment condensations
Haver,Smith
, p. 2239 - 2242 (1993)
The Izumiya tripeptide was used to assess racemization in solid-phase fragment condensations. Boc-Gly-Ala-OH1 was coupled to Leu-PAM resin with DIC in a variety of solvents, both with and without HOBt. After cleavage from the resin, the extent of racemization was determined using C18 RP-HPLC to separate the epimers. Solvents used were DMF, NMP, TFE, and each of these as mixtures with DCM. Also tested was a mixture of NMP and DMSO (85:15). Couplings in FMD/DCM (1:1) and NMP/DCM (1:1) in the presence of HOBt were in excess of 98% and racemization was undetectable (0.1%).
Amino Acids and Peptides. XXX. Phosphorus in Organic Synthesis. XVII. Application of Diphenyl Phosphorazidate (DPPA) and Diethyl Phosphorocyanidate (DEPC) to Solid-phase Peptide Synthesis
Ikota, Nobuo,Shioiri, Takayuki,Yamada, Shun-Ichi
, p. 3064 - 3069 (2007/10/02)
Two coupling reagents for peptide synthesis, diphenyl phosphorazidate (DPPA) and diethyl phosphorocyanidate (DEPC), were tested using the solid-phase method.The reactivities of DPPA and DEPC were examined by coupling Boc-Ile with Gly-resin.In a comparison
