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Cas Database

229485-67-0

229485-67-0

Identification

  • Product Name:β-chloro-β-phenylalanine

  • CAS Number: 229485-67-0

  • EINECS:

  • Molecular Weight:199.637

  • Molecular Formula: C9H10ClNO2

  • HS Code:

  • Mol File:229485-67-0.mol

Synonyms:β-chloro-β-phenylalanine

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Relevant articles and documentsAll total 1 Articles be found

ON THE SYNTHESIS OF β-PHENYLALANINE

Portelli, Mario

, p. 215 - 216 (2007/10/02)

A practical, economical and efficient two-step synthesis of β-phenylalanine and its methyl ester is reported: ?-phenylserine, 1, is chlorinated to β-chloro-β-phenylalanine, 2; the latter is hydrogenated in the presence of 10percent Pd/C catalyst to give the desired amino acid. β-Phenylalanine is separated (yield based upon β-phenylserine) as the free amino acid 3 (65.3percent yield) or as the hydrochloride 4 (79.8percent yield) or esterified to the methyl ester hydrochloride 5 (78.7percent yield).

Process route upstream and downstream products

Process route

benzaldehyde
100-52-7

benzaldehyde

β-chloro-β-phenylalanine
229485-67-0

β-chloro-β-phenylalanine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 74.8 percent / NaOH / methanol; H2O / 1.) 16 dg C, 30 min; 2.) RT, overnight
2: SOCl2 / 4 h
With sodium hydroxide; thionyl chloride; In methanol; water;
Phenylserin
69-96-5

Phenylserin

β-chloro-β-phenylalanine
229485-67-0

β-chloro-β-phenylalanine

Conditions
Conditions Yield
With thionyl chloride; for 4h;
benzaldehyde
100-52-7

benzaldehyde

β-chloro-β-phenylalanine
229485-67-0

β-chloro-β-phenylalanine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 74.8 percent / NaOH / methanol; H2O / 1.) 16 dg C, 30 min; 2.) RT, overnight
2: SOCl2 / 4 h
With sodium hydroxide; thionyl chloride; In methanol; water;
Phenylserin
69-96-5

Phenylserin

β-chloro-β-phenylalanine
229485-67-0

β-chloro-β-phenylalanine

Conditions
Conditions Yield
With thionyl chloride; for 4h;

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