23916-02-1Relevant academic research and scientific papers
Hydroamination of terminal alkynes with secondary amines catalyzed by copper: Regioselective access to amines
Bahri, Janet,Blieck, Rémi,Jamoussi, Bassem,Taillefer, Marc,Monnier, Florian
supporting information, p. 11210 - 11212 (2015/07/07)
A simple and convenient copper-catalyzed hydroamination of arylacetylenes with secondary amines has been performed giving a simple access to aliphatic amines after reduction of the hydroaminated products (E-enamines). Here we described a mild catalytic system utilizing CuCN precatalyst without any additive ligands in a solvent-free system.
Borrowing hydrogen methodology for amine synthesis under solvent-free microwave conditions
Watson, Andrew J. A.,Maxwell, Aoife C.,Williams, Jonathan M. J.
supporting information; experimental part, p. 2328 - 2331 (2011/05/17)
Application of microwave heating to the Borrowing Hydrogen strategy to form C-N bonds from alcohols and amines is presented, removing the need for solvent and reducing the reaction times while still yielding results comparable with those using thermal heating.
Borrowing hydrogen in water and ionic liquids: Iridium-catalyzed alkylation of amines with alcohols
Saidi, Ourida,Blacker, A. John,Lamb, Gareth W.,Marsden, Stephen P.,Taylor, James E.,Williams, Jonathan M. J.
supporting information; experimental part, p. 1046 - 1049 (2011/03/20)
The use of [Cp*IrI2]2 as an efficient catalyst for the alkylation of amines by alcohols in either water or ionic liquid is described. Primary amines are converted into secondary amines, and secondary amines into tertiary amines in the absence of base, and the chemistry has been applied to the synthesis of the analgesic fentanyl. The conversion of primary amines into N-heterocycles by the reaction with diols is also described, along with the N-alkylation of sulfonamides.
D2 Dopaminergic and 5-HT1A Serotonergic Activity of 2-(1-Naphthyl)ethyl- and 2-(2-Naphthyl)ethyl Amines
?ukalovi?,Rogli?,Husinec,Kosti?-Raja?i?,Andri?,?o?ki?, Vuki?
, p. 514 - 522 (2007/10/03)
Several tertiary 2-phenylethyl, 2-(1-naphthyl)ethyl and 2-(2-naphthyl) ethyl amines were synthesized and their binding affinities for dopamine D 1, D2 and serotonin 5-HT1A receptors evaluated in radioligand binding assays.
