N,N-Dipropylphenethylamine

Base Information

• Chemical Name: N,N-Dipropylphenethylamine
• CAS No.: 23916-02-1
• Molecular Formula: C14H23N
• Molecular Weight: 205.343
• Hs Code.: 2921199090
• DSSTox Substance ID: DTXSID50458714
• Nikkaji Number: J381.712A
• Wikidata: Q82282203
• Mol file: 23916-02-1.mol

Synonyms:N,N-Dipropylphenethylamine;23916-02-1;SCHEMBL552965;DTXSID50458714;AKOS017161717

Chemical Property of N,N-Dipropylphenethylamine

Chemical Property:

• PSA: 3.24000
• LogP: 3.35110
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 7
• Exact Mass: 205.183049738
• Heavy Atom Count: 15
• Complexity: 132

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN(CCC)CCC1=CC=CC=C1

Technology Process of N,N-Dipropylphenethylamine

There total 7 articles about N,N-Dipropylphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-phenylethanol (60-12-8) + di-n-propylamine (142-84-7) → N-2-(phenylethyl)-N,N-dipropyl-amine (23916-02-1)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; bis[2-(diphenylphosphino)phenyl] ether; at 125 ℃; for 1.5h; Inert atmosphere; Microwave irradiation; Neat (no solvent);

DOI:10.1021/jo102521a

Reference yield: 91.0%

N,N-dipropyl-2-phenylacetamide (25173-09-5) → N-2-(phenylethyl)-N,N-dipropyl-amine (23916-02-1)

Guidance literature:

With diborane; In tetrahydrofuran; for 1h; Heating;

DOI:10.1002/ardp.200300776

Reference yield:

(E)-N-propyl-N-styrylpropan-1-amine → N-2-(phenylethyl)-N,N-dipropyl-amine (23916-02-1)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1039/c5cc02677f

upstream raw materials:

N,N-dipropyl-2-phenylacetamide

phenylacetonitrile

di-n-propylamine

1-phenyl-2-bromoethane

Downstream raw materials:

5-{3-[2-(dipropylamino)ethyl]phenyl}-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide trifluoroacetate

Refernces

• 1、 Watson, Andrew J. A.,Maxwell, Aoife C.,Williams, Jonathan M. J.. "Borrowing hydrogen methodology for amine synthesis under solvent-free microwave conditions". supporting information; experimental part. p. 2328 - 2331. Retrieved 2011/05/17.
• 2、 ?ukalovi?,Rogli?,Husinec,Kosti?-Raja?i?,Andri?,?o?ki?, Vuki?. "D2 Dopaminergic and 5-HT1A Serotonergic Activity of 2-(1-Naphthyl)ethyl- and 2-(2-Naphthyl)ethyl Amines". . p. 514 - 522. Retrieved 2007/10/03.