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CAS

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2419-94-5

Boc-L-Glutamic acid, also known as N-Boc-protected L-Glutamic acid, is a derivative of the nonessential amino acid L-Glutamic acid. It plays a crucial role in the mammalian central nervous system and serves as a neurotransmitter for cone photoreceptors in the human brain. Boc-L-Glutamic acid is characterized by its white to off-white crystalline powder appearance.

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  • 2419-94-5 Structure

  • Basic information

    1. Product Name: Boc-L-Glutamic acid
    2. Synonyms: N-(TERT-BUTOXYCARBONYL)-L-GLUTAMIC ACID;N-T-BUTOXYCARBONYL-L-GLUTAMIC ACID;N-ALPHA-T-BOC-L-GLUTAMIC ACID;N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID;N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMIC ACID;BOC-GLU-OH;BOC-GLUTAMIC ACID-OH;BOC-L-GLU-OH
    3. CAS NO:2419-94-5
    4. Molecular Formula: C10H17NO6
    5. Molecular Weight: 247.25
    6. EINECS: 1533716-785-6
    7. Product Categories: Amino Acid Derivatives;Amino Acids;Glutamic acid [Glu, E];Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series
    8. Mol File: 2419-94-5.mol

  • Chemical Properties

    1. Melting Point: ~110 °C (dec.)
    2. Boiling Point: 390.28°C (rough estimate)
    3. Flash Point: 217.4 °C
    4. Appearance: white to off-white crystalline powder
    5. Density: 1.2868 (rough estimate)
    6. Vapor Pressure: 8.13E-09mmHg at 25°C
    7. Refractive Index: -15 ° (C=1, MeOH)
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 3.83±0.10(Predicted)
    11. Water Solubility: Soluble in water
    12. BRN: 2418563
    13. CAS DataBase Reference: Boc-L-Glutamic acid(CAS DataBase Reference)
    14. NIST Chemistry Reference: Boc-L-Glutamic acid(2419-94-5)
    15. EPA Substance Registry System: Boc-L-Glutamic acid(2419-94-5)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 20/21/22-36/37/38
    3. Safety Statements: 22-24/25-36-26-4/25
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2419-94-5(Hazardous Substances Data)

2419-94-5 Usage

Uses

Used in Pharmaceutical Industry:
Boc-L-Glutamic acid is used as an active pharmaceutical ingredient for the treatment of patients with liver disease accompanied by encephalopathy, also known as 'hepatic coma.' Its role in the central nervous system makes it a valuable compound in addressing this specific medical condition.
Used in Neurotransmission:
Boc-L-Glutamic acid is used as a neurotransmitter for cone photoreceptors in the human brain, playing a significant role in the proper functioning of the nervous system and maintaining overall brain health.
Used in Research and Development:
Due to its unique properties and applications, Boc-L-Glutamic acid is also utilized in research and development for the discovery of new pharmaceutical compounds and therapies targeting the central nervous system and related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 2419-94-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,1 and 9 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2419-94:
(6*2)+(5*4)+(4*1)+(3*9)+(2*9)+(1*4)=85
85 % 10 = 5
So 2419-94-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H17NO6/c1-10(2,3)17-9(16)11-6(8(14)15)4-5-7(12)13/h6H,4-5H2,1-3H3,(H,11,16)(H,12,13)(H,14,15)/t6-/m1/s1

2419-94-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • TCI America

  • (B2177)  N-(tert-Butoxycarbonyl)-L-glutamic Acid  >98.0%(T)

  • 2419-94-5

  • 25g

  • 830.00CNY

  • Detail

  • Alfa Aesar

  • (H59907)  N-Boc-L-glutamic acid, 98%   

  • 2419-94-5

  • 1g

  • 114.0CNY

  • Detail

  • Alfa Aesar

  • (H59907)  N-Boc-L-glutamic acid, 98%   

  • 2419-94-5

  • 5g

  • 285.0CNY

  • Detail

  • Aldrich

  • (15345)  Boc-Glu-OH  ≥98.0% (T)

  • 2419-94-5

  • 15345-5G

  • 299.52CNY

  • Detail

2419-94-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioic acid

1.2 Other means of identification

Product number -
Other names Boc-L-Glu-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2419-94-5 SDS

2419-94-5Relevant articles and documents

Enzymatic removal of carboxyl protecting groups. 2. Cleavage of the benzyl and methyl moieties

Barbayianni, Efrosini,Fotakopoulou, Irene,Schmidt, Marlen,Constantinou-Kokotou, Violetta,Bornscheuer, Uwe T.,Kokotos, George

, p. 8730 - 8733 (2007/10/03)

Enzymes are versatile reagents for the efficient removal of methyl and benzyl protecting groups. An esterase from Bacillus subtilis (BS2) and a lipase from Candida antarctica (CAL-A) allow a mild and selective removal of these moieties in high yields without affecting other functional groups.

Preferential hydrogenolysis of NAP esters provides a new orthogonal protecting group strategy for carboxylic acids

Gaunt, Matthew J.,Boschetti, Carlos E.,Yu, Jinquan,Spencer, Jonathan B.

, p. 1803 - 1806 (2007/10/03)

Selective hydrogenolysis of 2-naphthylmethyl (NAP) esters in the presence of a benzyl ester has been observed with a wide range of dicarboxylic acids. Orthogonal deprotection of NAP esters with challenging substrates can be achieved if the other carboxylic acids in the molecule are protected with 4-trifluoromethyl benzyl group instead of benzyl groups.

PROPERTIES OF Nα,Nca-DI-TERT-BUTYLOXYCARBONYL-ω-CARBAMOYL-α-AMINO ACIDS AND DIRECT SYNTHESIS OF PROTECTED HOMOGLUTAMIC ACID DERIVATIVES

Sakura, Naoki,Hirose, Kyoko,Hashimoto, Tadashi

, p. 3506 - 3509 (2007/10/02)

The protected carboxamide function of Nα,Nca-di-tert-butyloxy-carbonyl-ω-carbamoyl-α-amino acids worked well with nucleophilic reagents.Applying this novel reactivity, we developed an efficient synthetic route to Nα-tert-butyloxycarbonylhomoglutamic acid and its derivatives, including Nα-tert-butyloxycarbonylhomoglutamic acid δ-benzyl ester, from Nα,Nca-di-tert-butyloxycarbonylhomoglutamine.KEYWORDS - protected homoglutamic acid synthesis; Nca-tert-butyloxycarbonylated carboxamide; hydrolysis; selective deprotection; Nα-tert-butyloxycarbonylhomoglutamic acid δ-benzyl ester; Nα-tert-butyloxycarbonylhomoglutamic acid α-tert-butyl ester; Nα-tert-butyloxycarbonylhomoglutamine; optical purity

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