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Cas Database

24250-85-9

24250-85-9

Identification

  • Product Name:L-4-Iodophenylalanine

  • CAS Number: 24250-85-9

  • EINECS:

  • Molecular Weight:291.088

  • Molecular Formula: C9H10INO2

  • HS Code:2922499990

  • Mol File:24250-85-9.mol

Synonyms:p-Iodo-L-phenylalanine;H-Phe(4-I)-OH;Alanine,3-(p-iodophenyl)-, L- (8CI);4-Iodo-L-phenylalanine;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:Usbiological
  • Product Description:4-Iodo-L-phenylalanine
  • Packaging:2g
  • Price:$ 333
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:4-Iodo-L-phenylalanine
  • Packaging:500mg
  • Price:$ 65
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  • Manufacture/Brand:TRC
  • Product Description:4-Iodo-L-phenylalanine
  • Packaging:100mg
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Iodo-L-phenylalanine
  • Packaging:1 g
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Iodo-L-phenylalanine
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  • Manufacture/Brand:Sigma-Aldrich
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:4-Iodo-L-phenylalanine 95+%
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:4-Iodo-L-phenylalanine 95+%
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  • Manufacture/Brand:Matrix Scientific
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  • Manufacture/Brand:Matrix Scientific
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Relevant articles and documentsAll total 32 Articles be found

PRODUCTION METHOD FOR RADIOLABELED ARYL COMPOUND

-

Paragraph 0208, (2020/12/10)

The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X is 211At, 210At, 123I, 124I, 125I, or 131I. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)2) or an ester group thereof, with a radionuclide selected from 211At, 210At, 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes

Hebel, Marco,Riegger, Andreas,Zegota, Maksymilian M.,Kizilsavas, G?nül,Ga?anin, Jasmina,Pieszka, Michaela,Lückerath, Thorsten,Coelho, Jaime A. S.,Wagner, Manfred,Gois, Pedro M. P.,Ng, David Y. W.,Weil, Tanja

supporting information, p. 14026 - 14031 (2019/10/11)

The development of a synthetic code that enables a sequence programmable feature like DNA represents a key aspect toward intelligent molecular systems. We developed herein the well-known dynamic covalent interaction between boronic acids (BAs) and catechols (CAs) into synthetic nucleobase analogs. Along a defined peptide backbone, BA or CA residues are arranged to enable sequence recognition to their complementary strand. Dynamic strand displacement and errors were elucidated thermodynamically to show that sequences are able to specifically select their partners. Unlike DNA, the pH dependency of BA/CA binding enables the dehybridization of complementary strands at pH 5.0. In addition, we demonstrate the sequence recognition at the macromolecular level by conjugating the cytochrome c protein to a complementary polyethylene glycol chain in a site-directed fashion.

PENTAFLUOROPHOSPHATE DERIVATIVE, ITS USES AND AN APPROPRIATE MANUFACTURING METHOD

-

Page/Page column 12, (2019/04/05)

The invention relates to a pentafluorophosphate derivative according to general formula (I): or a pharmaceutically acceptable salt or solvate thereof. Thereby, R1 and R2 denote independently from each other H or F; R3 denotes H, an optionally substituted C1-C10 alkyl, an optionally substituted C3-C10 cycloalkyl, or an optionally substituted C6-C20 aryl, wherein a hydrocarbon chain of the alkyl, the cycloalkyl or the aryl can be interrupted by one or more oxygen, sulfur and/or nitrogen atoms; and M denotes any cation; with the proviso that at least one of R1 and R2 denotes F, if R3 denotes H. The invention further relates to uses of such a pentafluorophosphate derivative and to an appropriate manufacturing method.

Photoinduced Hydroxylation of Organic Halides under Mild Conditions

Cai, Yue-Ming,Xu, Yu-Ting,Zhang, Xin,Gao, Wen-Xia,Huang, Xiao-Bo,Zhou, Yun-Bing,Liu, Miao-Chang,Wu, Hua-Yue

supporting information, p. 8479 - 8484 (2019/10/16)

Presented in this paper is photoinduced hydroxylation of organic halides, providing a mild access to a range of functionalized phenols and aliphatic alcohols. These reactions generally proceed under mild reaction conditions with no need for a photocatalyst or a strong base and show a wide substrate scope as well as excellent functional group tolerance. This work highlights the unique role of NaI that allows a challenging transformation to proceed under mild reaction conditions.

Site-Selective Modification of α-Amino Acids and Oligopeptides via Native Amine-Directed γ-C(sp3)-H Arylation

Yuan, Feipeng,Hou, Zhen-Lin,Pramanick, Pranab K.,Yao, Bo

supporting information, p. 9381 - 9385 (2019/11/28)

Site-selective modification of chemically and biologically valuable α-amino acids and peptides is of great importance for biochemical study and pharmaceutical development. Few methods based on remote C(sp3)-H functionalization of aliphatic side-chains of peptides has been disclosed in recent years. In this report, we developed a novel approach for γ-C(sp3)-H and γ-/δ-C(sp2)-H arylation of α-amino acids with α-hydrogen by native amine-directed C-H functionalization and further realized the γ-C(sp3)-H arylation of N-terminally unprotected peptides.

Process route upstream and downstream products

Process route

p-borono-L-phenylalanine
76410-58-7

p-borono-L-phenylalanine

Conditions
Conditions Yield
With N-Bromosuccinimide; sodium hydrogencarbonate; sodium iodide; In water; at 20 ℃; for 0.5h;
p-amino-L-phenylalanine hydrochloride
62040-55-5

p-amino-L-phenylalanine hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; potassium iodide; copper(II) oxide; sodium nitrite; Multistep reaction; 1.) water, reflux, 45 min; 2.) water, 0 deg C, 30 min; reflux;
Conditions
Conditions Yield
Conditions
Conditions Yield
With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; for 18h; regioselective reaction;
48%
Conditions
Conditions Yield
With ammonia; at 37 ℃;
Conditions
Conditions Yield
With potassium iodide; at 50 ℃;
Conditions
Conditions Yield
With potassium carbonate; man digeriert den nach dem Verdampfen des Alkohols durch Salzsaeure gefaellten Niederschlag mit Salzsaeure;
1-bromomethyl-4-iodobenzene
16004-15-2

1-bromomethyl-4-iodobenzene

2-acetylaminomalonic acid diethyl ester
1068-90-2

2-acetylaminomalonic acid diethyl ester

Conditions
Conditions Yield
Multistep reaction; (i) NaOEt, (ii) aq. HCl;
Conditions
Conditions Yield
Conditions
Conditions Yield
L-phenylalanine; With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; for 18h;
With sodium hydroxide; In methanol; water;
100%
With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; for 18h;
100%
L-phenylalanine; With sodium iodate; iodine; In sulfuric acid; acetic acid; at 70 ℃; for 20h;
With sodium periodate; In sulfuric acid; acetic acid;
87%
With sulfuric acid; iodine; acetic acid; sodium iodide; at 70 ℃; for 21h;
87%
With sodium periodate; sulfuric acid; iodine; acetic acid; at 70 ℃;
86%
L-phenylalanine; With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; Reflux;
With sodium periodate; In acetic acid; at 70 ℃; for 1h;
81%
With sulfuric acid; iodine; acetic acid; at 70 ℃; for 21h; Inert atmosphere;
75%
With sodium iodate; sulfuric acid; iodine; acetic acid;
71%
L-phenylalanine; With sodium iodate; sulfuric acid; iodine; acetic acid; at 70 ℃; for 24h; Inert atmosphere;
With sodium periodate; In sulfuric acid; acetic acid; at 70 ℃; for 4h; Inert atmosphere;
71%
With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃;
60%
L-phenylalanine; With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; for 18h;
With sodium periodate; In acetic acid; at 70 ℃; for 0.5h;
57%
L-phenylalanine; With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; for 18h;
With sodium periodate; In acetic acid; at 70 ℃; for 0.5h;
57%
L-phenylalanine; With sodium iodate; sulfuric acid; iodine; acetic acid; at 70 ℃; for 18h;
With sodium periodate; at 70 ℃; for 0.5h;
57%
With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; for 21h;
53%
With sodium iodate; sulfuric acid; iodine; In acetic acid;
53%
With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; for 21h;
53%
With sodium iodate; sulfuric acid; iodine; acetic acid; at 70 ℃; for 24h;
50%
With sodium iodate; sulfuric acid; iodine; In acetic acid; at 70 ℃; for 70h;
45%
With potassium iodate; iodine; In sulfuric acid; acetic acid; at 80 ℃;
44%
With sodium iodate; sulfuric acid; iodine; In acetic acid;
With sodium iodate; sulfuric acid; iodine; acetic acid;
L-phenylalanine; With sodium iodate; sulfuric acid; iodine; acetic acid; at 70 ℃; for 24h;
With sodium periodate; for 0.5h;
With sodium hydroxide; In water; pH=5;
With sulfuric acid; HK*IO3(1-); iodine; acetic acid;
With peracetic acid; sulfuric acid; iodine; acetic acid; In water; at 20 - 60 ℃; for 2 - 4h;
With sodium periodate; sodium iodate; sulfuric acid; iodine; acetic acid; at 70 ℃;
L-phenylalanine; With sodium iodate; sulfuric acid; iodine; acetic acid; at 70 ℃; for 24h; Schlenk technique; Inert atmosphere;
With sodium periodate; at 70 ℃; for 4h; Schlenk technique; Inert atmosphere;
With sodium iodate; sulfuric acid; iodine; acetic acid; at 70 ℃;

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