247237-54-3

Basic information

• Product Name: 3-[(4-chlorophenyl)sulfanyl]-4-hydroxy-1-methyl-2(1H)-quinolinone
• Synonyms: 3-[(4-chlorophenyl)sulfanyl]-4-hydroxy-1-methyl-2(1H)-quinolinone
• CAS NO: 247237-54-3
• Molecular Formula: C₁₆H₁₂ClNO₂S
• Molecular Weight: 317.78998
• Mol File: 247237-54-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[(4-chlorophenyl)sulfanyl]-4-hydroxy-1-methyl-2(1H)-quinolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-chlorophenyl)sulfanyl]-4-hydroxy-1-methyl-2(1H)-quinolinone(247237-54-3)
• EPA Substance Registry System: 3-[(4-chlorophenyl)sulfanyl]-4-hydroxy-1-methyl-2(1H)-quinolinone(247237-54-3)

Safety Data

• Hazardous Substances Data: 247237-54-3(Hazardous Substances Data)

Upstream product

• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 106-54-7 p-Chlorothiophenol 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 69380-26-3 3-(4-chlorophenylsulfonyl)-4-hydroxy-1-methyl-2(1H)-quinolone 
• 69146-81-2 3-(4-chlorophenylsulfinyl)-4-hydroxy-1-methyl-2(1H)-quinolone 

Relevant articles and documents

3-Thioaryl-4-hydroxyquinolinone derivative and synthetic method thereof

The invention relates to quinolinone derivatives, in particular to a 3-thioaryl-4-hydroxyquinolinone derivative and a synthetic method thereof, and belongs to the field of organic chemistry. The 3-thioaryl-4-hydroxyquinolinone derivative is prepared by using 4-hydroxyquinolinone, sulfur powder and an iodobenzene derivative as raw materials, adding a ligand, an alkali source and a catalyst, and allowing reaction in a solvent. The sulfur source used herein is cheap and easy to obtain, has stable properties and is environmentally friendly; the synthetic method has mild conditions and is simple tooperate, low in cost and free of toxic and harmful effects. The 3-thioaryl-4-hydroxyquinolinone derivative has great application potential in the field of medicine. The invention provides a novel means to synthesize the 3-thioaryl-4-hydroxyquinolinone derivative.

Copper-Mediated Direct Sulfenylation of 4-Hydroxyquinolinones and 4-Hydroxypyridones with Aryl Thiols via a C-H Functionalization Process

An efficient approach for the direct sulfanylation of 4-hydroxyquinolinones and 4-hydroxypyridones with aryl thiols in the presence of CuI/DMSO has been developed. The substrate scope is broad, allowing facile synthesis of a range of structurally diverse 3-sulfanyl-4-hydroxyquinolinones and 3-sulfanyl-4-hydroxypyridones in good efficiency.

Ammonium Iodide-Mediated Sulfenylation of 4-Hydroxycoumarins or 4-Hydroxyquinolinones with a Sulfonyl Chloride as a Sulfur Source

A novel ammonium iodide-induced sulfenylation of 4-hydroxycoumarins or 4-hydroxyquinolinones by using an aryl- or alkylsulfonyl chloride as the sulfur source gave a wide range of 3-sulfanyl-4-hydroxycoumarins or 3-sulfanyl-4-hydroxyquinolinones, respectiv

Sulfenylation of heterocyclic 1,3-dicarbonyl compounds

Anions of heteroaromatic 1,3-dicarbonyl compounds, such as 4-hydoxy-2-quinolones and 4-hydroxy-coumarins, react in DMF in the presence of potassium carbonate with diaryl disulfides to yield 3-arylsulfenyl derivatives. The arylthiolate anions formed in thi