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24890-52-6

24890-52-6

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  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 4 Articles be found

Al(OTf)3: An efficient lewis acid additive for domino addition-elimination of Grignard reagents to activated ketones

Pieterse, Tanya,Visser, Melanie,Marais, Charlene,Bezuidenhoudt, Barend C. B.

supporting information, p. 1541 - 1546 (2016/06/14)

It has been demonstrated that aluminium triflate in either stoichiometric or catalytic quantities facilitates the addition-elimination of Grignard reagents to electron-rich ketones, such as methoxy substituted acetophenones, propiophenone and chromanone in a one-pot process, and that it has an enhancing effect on the addition of these reagents to the ketones. It has also been found that the reactions are highly stereoselective towards one regioisomer of the alkene in the case of oxygenated aryl-alkyl substituted substrates, but not when the elimination originates from a double benzylic alcohol intermediate.

Synthesis of 1,1-diarylethylenes

Chang, Meng-Yang,Huang, Yi-Hsuan,Wang, Heui-Sin

, p. 3022 - 3031 (2016/05/19)

A facile route toward 1,1-diarylethylenes 6 has been developed in good yields via mCPBA-promoted oxidation of β-hydroxysulfides 2, BF3·OEt2-mediated Friedel-Crafts reaction of the resulting β-hydroxysulfoxides 3 with oxygenated benze

Mechanistic studies of photohydration of m-hydroxy-1,1-diaryl alkenes

Cole, John G.,Wan, Peter

, p. 46 - 54 (2007/10/03)

The photohydration of a variety of m-hydroxy-1,1-diaryl alkenes (8-10) and related systems (11 and 12) has been studied in aqueous CH3CN solution. All of these alkenes photohydrate efficiently in 1:1 H2O-CH3CN, to give the corresponding 1,1-diarylethanol (Markovnikov addition) products with high chemical and quantum yields. The aim of this study was to further probe the mechanism of photohydration reported for the parent m-hydroxy-α-phenylstyrene (5), which has been proposed as consisting of a water trimer-mediated excited state (formal) intramolecular proton transfer (ESIPT) from the phenolic proton to the β-carbon of the alkene moiety to give an observable (by laser flash photolysis (LFP)) m-quinone methide intermediate 6. For this purpose, derivatives of 5 with substituents (methyl or methoxy) on the α-phenyl ring as well as related model compounds were explored. Product studies, quantum yields, fluorescence, and nanosecond laser flash data are reported that are consistent with two distinct mechanisms for photohydration of these compounds: one involving water-mediated ESIPT (8, 9), as observed for the parent compound 5, and one involving direct protonation of the β-carbon by solvent water (11 and 12), with compound 10 possibly operating via both mechanisms.

ARYLALKENYLATION OF DIMETHOXYBENZENES WITH PHENYLACETYLENE

Zinov'eva, L.V.,Ryabov, V.D.

, p. 540 - 545 (2007/10/02)

During the arylalkenylation of dimethoxybenzenes with phenylacetylene in the presence of the catalysts H3PO4*BF3, KU-2, and (C2H5)2O*BF3 α-arylstyrenes or their cyclodimers derivatives of indane (from 1,2- and 1,4-dimethoxybenzenes) or derivatives of ind

Process route upstream and downstream products

Process route

C<sub>22</sub>H<sub>22</sub>O<sub>3</sub>S

C22H22O3S

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
With 5%-palladium/activated carbon; In ethanol; at 20 ℃; for 0.333333h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;
89%
2',4'-dimethoxyacetophenone
829-20-9

2',4'-dimethoxyacetophenone

phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
2',4'-dimethoxyacetophenone; With aluminium(III) triflate; In dichloromethane; at -30 ℃; for 0.5h; Inert atmosphere;
phenylmagnesium bromide; In diethyl ether; dichloromethane; at -30 - 20 ℃; for 24h; Inert atmosphere;
62%
2',4'-dimethoxy-1,1-diphenylethanol
3671-05-4

2',4'-dimethoxy-1,1-diphenylethanol

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
With sulfuric acid; In tetrahydrofuran; Heating;
90%
1-Bromo-2,4-dimethoxybenzene
17715-69-4

1-Bromo-2,4-dimethoxybenzene

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: Mg / tetrahydrofuran / Heating
1.2: 45 percent / tetrahydrofuran / Heating
2.1: 90 percent / aq. H2SO4 / tetrahydrofuran / Heating
With sulfuric acid; magnesium; In tetrahydrofuran; 1.2: Grignard reaction;
acetophenone
98-86-2

acetophenone

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: Mg / tetrahydrofuran / Heating
1.2: 45 percent / tetrahydrofuran / Heating
2.1: 90 percent / aq. H2SO4 / tetrahydrofuran / Heating
With sulfuric acid; magnesium; In tetrahydrofuran; 1.2: Grignard reaction;
1-phenyl-2-(phenylthio)ethanone
16222-10-9

1-phenyl-2-(phenylthio)ethanone

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / 0.17 h / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
3: boron trifluoride diethyl etherate / dichloromethane / 0.33 h / 20 °C / Inert atmosphere
4: 5%-palladium/activated carbon / ethanol / 0.33 h / 20 °C / Inert atmosphere
With sodium tetrahydroborate; 5%-palladium/activated carbon; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; 3: |Friedel-Crafts Alkylation;
1-phenyl-2-phenylsulfanyl-ethanol
67210-34-8,67210-39-3,121053-49-4,16162-51-9

1-phenyl-2-phenylsulfanyl-ethanol

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
2: boron trifluoride diethyl etherate / dichloromethane / 0.33 h / 20 °C / Inert atmosphere
3: 5%-palladium/activated carbon / ethanol / 0.33 h / 20 °C / Inert atmosphere
With 5%-palladium/activated carbon; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; 2: |Friedel-Crafts Alkylation;
erythro-2-(phenylsulfinyl)-1-phenyl-1-ethanol
49639-26-1

erythro-2-(phenylsulfinyl)-1-phenyl-1-ethanol

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: boron trifluoride diethyl etherate / dichloromethane / 0.33 h / 20 °C / Inert atmosphere
2: 5%-palladium/activated carbon / ethanol / 0.33 h / 20 °C / Inert atmosphere
With 5%-palladium/activated carbon; boron trifluoride diethyl etherate; In ethanol; dichloromethane; 1: |Friedel-Crafts Alkylation;
2-{2-[(2-hydroxy-2-phenylethyl)sulfanyl]ethylsulfanyl}-1-phenyl-1-ethanol
350031-26-4

2-{2-[(2-hydroxy-2-phenylethyl)sulfanyl]ethylsulfanyl}-1-phenyl-1-ethanol

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid
2: boron trifluoride diethyl etherate
3: 5%-palladium/activated carbon
With 5%-palladium/activated carbon; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; 2: |Friedel-Crafts Alkylation;
C<sub>18</sub>H<sub>22</sub>O<sub>4</sub>S<sub>2</sub>

C18H22O4S2

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene
24890-52-6

1-phenyl-1-(2,4-dimethoxyphenyl)ethylene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: boron trifluoride diethyl etherate
2: 5%-palladium/activated carbon
With 5%-palladium/activated carbon; boron trifluoride diethyl etherate; 1: |Friedel-Crafts Alkylation;

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