2527-59-5

Basic information

• Product Name: 2,2'-dithiobis[N-ethylbenzamide]
• Synonyms: 2,2'-dithiobis[N-ethylbenzamide]
• CAS NO: 2527-59-5
• Molecular Formula: C18H20N2O2S2
• Molecular Weight: 360.4936
• EINECS: 219-769-0
• Mol File: 2527-59-5.mol

Chemical Properties

• Boiling Point: 570.1°Cat760mmHg
• Flash Point: 298.6°C
• Appearance: /
• Density: 1.26g/cm³
• CAS DataBase Reference: 2,2'-dithiobis[N-ethylbenzamide](CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-dithiobis[N-ethylbenzamide](2527-59-5)
• EPA Substance Registry System: 2,2'-dithiobis[N-ethylbenzamide](2527-59-5)

Safety Data

• Hazardous Substances Data: 2527-59-5(Hazardous Substances Data)

Usage

Uses

Used in Water Treatment:
2,2'-dithiobis[N-ethylbenzamide] is used as a chelating agent for sequestering metal contaminants in water treatment processes. Its ability to bind metal ions helps in removing unwanted metals from water, making it a valuable component in environmental remediation.
Used in Pharmaceutical Applications:
2,2'-dithiobis[N-ethylbenzamide] is used as an active ingredient in the production of certain medications. Its chelating properties enable it to interact with metal ions in the body, which can be beneficial for various therapeutic applications.
Used in Personal Care Products:
2,2'-dithiobis[N-ethylbenzamide] is used as a chelating agent in personal care products, such as cosmetics and skincare formulations. Its ability to bind metal ions can help improve the stability and effectiveness of these products.
Environmental Considerations:
While 2,2'-dithiobis[N-ethylbenzamide] has numerous applications, it is important to note that it is toxic to aquatic organisms. Therefore, proper management and disposal of EDTA-containing products are crucial to minimize its potential harmful effects on the environment.

Upstream product

• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 75-04-7 ethylamine 
• 4299-06-3 2-Ethylbenzisothiazolin-3-on 
• 65382-84-5 2-Mercapto-N-ethyl-benzamid 
• 119-80-2 2,2'-dithiobenzoic acid 
• 80031-02-3 2-Bromo-N-ethylbenzamide 

Downstream Products

• 4299-06-3 2-Ethylbenzisothiazolin-3-on 
• 65382-84-5 2-Mercapto-N-ethyl-benzamid 
• 18712-20-4 2-ethyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide 

Relevant articles and documents

Preparation method of chemical intermediate 2,2'-dithiobenzamide compound

The invention provides a preparation method of a chemical intermediate 2,2'-dithiobenzamide compound, which comprises the following steps: reacting a 2-substituted benzamide compound with a sulfur reagent in an aprotic solvent with a high boiling point under the combined action of a metal salt and a ligand to generate a 2,2'-dithiobenzamide compound. The 2,2'-dithiobenzamide compound provided by the invention is an important chemical intermediate, the synthetic process route is simple, and the pollution of three wastes to the environment is reduced while the cost is reduced.

Crucial role of selenium in the virucidal activity of benzisoselenazol- 3(2h)-ones and related diselenides

Various N-substituted benzisoselenazol-3(2H)-ones and their non-seleniumcontaining analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogues having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogues of benzisoselenazol- 3(2H)-ones-diselenides also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses.

A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2'-dithiobisbenzamides

As part of the National Cancer Institute's Drug Screening Program, a new class of antiretrovirals active against the human immunodeficiency virus HIV-1 has been identified, and the HIV-1 nucleocapsid protein NCp7 was proposed as the target of antiviral action. The 2,2'-dithiobis-[4'-(sulfamoyl)benzanilide] (3x) and the 2,2'-dithiobis(5-acetylamino)benzamide (10) represented the prototypic lead structures. A wide variety of 2,2'-dithiobisbenzamides were prepared and tested for anti-HIV-1 activity, cytotoxicity, and their ability to extrude zinc from the zinc fingers for NCp7. The structure-activity relationships demonstrated that the ability to extrude zinc from NCp7 resided in the 2,2'-dithiobisbenzamide core structure. The 3,3' and the 4,4' isomers were inactive. While many analogs based upon the core structure retained the zinc extrusion activity, the best overall anti-HIV-1 activity was only found in a narrow set of derivatives possessing carboxylic acid, carboxamide, or phenylsulfonamide functional groups. These functional groups were more important for reducing cytotoxicity than improving antiviral potency or activity vs NCp7. All of the compounds with antiviral activity also extruded zinc from NCp7. From this study several classes of low μM anti-HIV agents with simple chemical structures were identified as possible chemotherapeutic agents for the treatment of AIDS.

Antithrombotic agent

Certain 2,2'-dithiobis-N-substituted or unsubstituted benzamides or derivatives thereof are useful as antithrombotic agents because of their ability to suppress aggregation of blood platelets.

DISPROPORTIONIERUNGEN VON DIPHENYLDISULFIDEN ZU 1.2-BENZISOTHIAZOLEN UND o-SUBSTITUIERTEN THIOPHENOLEN UNTER ANCHIMERER BETEILIGUNG VON ORTHOSTAENDIGEN AMID-, THIOAMID- UND AMIDIN-GRUPPEN

Substituents in the ortho position provide anchimeric support in the dissociation of diphenylsulphides.The carbamoyl group has only a weak effect.Support increases from an N,N'-disubstituted guanyl group, over thioamide to a guanyl group with an unsubstituted nitrogen atom, which effects an almost completely reversible cleavage of the disulphide group.