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2567-51-3

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  • Acetamide,2-chloro-N,N-bis(phenylmethyl)-

    Cas No: 2567-51-3

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2567-51-3 Usage

Uses

N,N-Dibenzyl-2-chloroacetamide (cas# 2567-51-3) is a useful reactant for the diastereo-/chemoselective preparation of vinyl silanes/silyl-substituted alpha, beta-unsaturated amides by Pd-catalyzed olefination.

Check Digit Verification of cas no

The CAS Registry Mumber 2567-51-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,6 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2567-51:
(6*2)+(5*5)+(4*6)+(3*7)+(2*5)+(1*1)=93
93 % 10 = 3
So 2567-51-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H16ClNO/c17-11-16(19)18(12-14-7-3-1-4-8-14)13-15-9-5-2-6-10-15/h1-10H,11-13H2

2567-51-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-DIBENZYL-2-CHLOROACETAMIDE

1.2 Other means of identification

Product number -
Other names chloro-acetic acid dibenzylamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2567-51-3 SDS

2567-51-3Relevant articles and documents

Tauroursodeoxycholic acid derivative, and pharmaceutical composition and preparation containing same

-

Paragraph 0089-0094, (2021/01/11)

The invention provides a tauroursodeoxycholic acid derivative, a pharmaceutical composition and a preparation containing the tauroursodeoxycholic acid derivative and pharmaceutical application. The tauroursodeoxycholic acid derivative has a structure repr

Latent Bronsted Base Solvent-Assisted Amide Formation from Amines and Acid Chlorides

Otsuka, Rikuto,Maruhashi, Kazuo,Ohwada, Tomohiko

supporting information, p. 2041 - 2057 (2018/05/04)

Weakly basic amines, including even neutral amines such as nitroaniline and aminocarboxylic acids, react with acid chlorides very efficiently in N, N -dimethylacetamide (DMAC), without addition of a base, to give the corresponding amides in high yields. The role of DMAC and related solvents as latent Bronsted bases was studied in these amidation reactions. Less basic amines, such as aromatic amines, reacted with benzoyl chloride faster than more basic aliphatic amines.

Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents

Ji, Qinggang,Yang, Dan,Wang, Xin,Chen, Chunyan,Deng, Qiao,Ge, Zhiqiang,Yuan, Lvjiang,Yang, Xiaolan,Liao, Fei

, p. 3405 - 3413 (2014/06/23)

A series of novel 1-methyl-3-substituted quinazoline-2,4-dione derivatives were designed, synthesized, and characterized by 1H NMR, 13C NMR and MS spectral data. Their inhibition against chitin synthase (CHS) and antifungal activities were evaluated in vitro. Results showed compounds 5b, 5c, 5e, 5f, 5j, 5k, 5l, and 5o had strong inhibitory potency against CHS. Compound 5c, which has the highest potency among these compounds, had a half-inhibition concentration (IC50) of 0.08 mmol/L, while polyoxin B as positive drug had IC50 of 0.18 mmol/L. These IC 50 values of compounds 5i, 5m, 5n, and 5s were greater than 0.75 mmol/L, which revealed that those compounds had weak inhibition activity against CHS. Moreover, most of these compounds exhibited moderate to excellent antifungal activities. In detail, to Candida albicans, the activities of compound 5g and 5k were 8-fold stronger than that of fluconazole and 4-fold stronger than that of polyoxin B; to Aspergillus flavus, the activities of 5g, 5l and 5o were16-fold stronger than that of fluconazole and 8-fold stronger than that of polyoxin B; to Cryptococcus neoformans, the minimum-inhibition- concentration (MIC) values of compounds 5c, 5d, 5e and 5l were comparable to those of fluconazole and polyoxin B. The antifungal activities of these compounds were positively correlated to their IC50 values against CHS. Furthermore, these compounds had negligible actions to bacteria. Therefore, these compounds were promising selective antifungal agents.

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