25975-59-1Relevant articles and documents
OXIDATIVE β-FRAGMENTATION OF 19-NOR-5α-ANDROSTANE-3β,5,17β-TRIOL 3,17-DIACETATE
Lorenc, Ljubinka,Bondarenko, Lidija,Rajkovic, Milica,Milovanovic, Aleksandar,Mihailovic, Lj. Mihailo
, p. 3609 - 3614 (1983)
The preparation of 19-nor-5α-androstane-3β,5,17β-triol 3,17-diacetate (10) is described.When this alcohol was treated with the mercuric oxide-iodine reagent, it underwent fragmentation of the C(5)-C(10) bond with formation of a new type of 10-membered ring containing 5,10-seco-steroidal compounds, i.e. (Z)-and (E)-19-nor-3β,17β-diacetoxy-5,10-seco-androst-1(10)-en-5-one (11 and 12), in 27 and 49percent yield, respectively.
PROGESTERONE RECEPTOR ANTAGONISTS AND USES THEREOF
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Page/Page column 68; 70, (2011/11/30)
The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.