2621-99-0

Basic information

• Product Name: N-[4-(aminosulphonyl)phenyl]acrylamide
• Synonyms: N-[4-(aminosulphonyl)phenyl]acrylamide;N-[4-(Aminosulfonyl)phenyl]acrylamide;N-[4-(Aminosulfonyl)phenyl]propenamide;N-[4-(aMinosuIfonyI)phenyI]acrylaMide;N-(4-sulfamoylphenyl)prop-2-enamide
• CAS NO: 2621-99-0
• Molecular Formula: C₉H₁₀N₂O₃S
• Molecular Weight: 226.2523
• EINECS: 220-066-6
• Mol File: 2621-99-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 215 °C
• Appearance: /
• Density: 1.387 g/cm³
• Refractive Index: 1.611
• PKA: 9.89±0.12(Predicted)
• CAS DataBase Reference: N-[4-(aminosulphonyl)phenyl]acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(aminosulphonyl)phenyl]acrylamide(2621-99-0)
• EPA Substance Registry System: N-[4-(aminosulphonyl)phenyl]acrylamide(2621-99-0)

Safety Data

• Hazardous Substances Data: 2621-99-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C9H10N2O3S/c1-2-9(12)11-7-3-5-8(6-4-7)15(10,13)14/h2-6H,1H2,(H,11,12)(H2,10,13,14)

Upstream product

• 2051-76-5 acrylic acid anhydride 
• 63-74-1 sulfanilamide 
• 814-68-6 acryloyl chloride 

Relevant articles and documents

Polymeric drug based on sulfanilamide: Synthesis, antimicrobial and drug releasing studies

N-((4-amino sulfonyl)phenyl)acrylamide (APA) was synthesized using sulfanilamide and acryloyl chloride in the presence of triethyl amine at 0-5°C. Homo- and co-polymerization of 2-hydroxyethyl acrylate (HEA) and acrylic acid (AA) were done by adopting a solution polymerization technique using methyl ethyl ketone (MEK) as a solvent and benzoyl peroxide (BPO) as a free radical initiator at 70 ± 1°C. All the monomers and polymers were characterized by IR and NMR techniques. These monomers and polymers were tested for their antimicrobial activity against five different ATCC strain microorganisms (Escherichia coli (25922), Pseudomonas aeruginosa (27853), Klebsiella (70063), Salmonella typhi (6539) and Staphylococcus aureus (25923)). The effect of co-monomer, other than the active drug moiety present in the polymeric drug, is discussed. The antimicrobial activity of APA on Gram-positive bacteria was enhanced when copolymerized with AA and HEA. The polymer was made into a film form and that film was used for drug releasing study. The drug releasing rate was monitored by the absorption at 268 nm using a UV spectrophotometer. The effect of pH and the temperature on the drug releasing rate was monitored and found that the releasing rate was dependent on the co-monomer, pH and temperature of the medium.