265107-41-3

Basic information

• Product Name: Ethanone, 1-[6-(dimethylamino)-3-pyridinyl]- (9CI)
• Synonyms: 1-[6-(dimethylamino)-3-pyridinyl]ethanone;Ethanone, 1-[6-(dimethylamino)-3-pyridinyl]- (9CI);1-(6-(dimethylamino)pyridin-3-yl)ethanone
• CAS NO: 265107-41-3
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.20438
• Product Categories: ACETYLGROUP
• Mol File: 265107-41-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 63.8-64.2 °C
• Boiling Point: 309.7±27.0 °C(Predicted)
• Appearance: /
• Density: 1.078±0.06 g/cm3(Predicted)
• PKA: 5.20±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-[6-(dimethylamino)-3-pyridinyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[6-(dimethylamino)-3-pyridinyl]- (9CI)(265107-41-3)
• EPA Substance Registry System: Ethanone, 1-[6-(dimethylamino)-3-pyridinyl]- (9CI)(265107-41-3)

Safety Data

• Hazardous Substances Data: 265107-41-3(Hazardous Substances Data)

Upstream product

• 55676-22-7 3-acetyl-6-chloropyridine 
• 124-40-3 dimethyl amine 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 923034-23-5 dimethyl 2-(6-chloronicotinoyl)malonate 

Downstream Products

• 856014-52-3 2-amino-4-(3-bromophenyl)-6-(2-dimethylamino-5-pyridyl)nicotinonitrile 

Relevant articles and documents

Acetylation of N-heteroaryl bromides via PdCl2/(o-tolyl) 3P catalyzed heck reactions

A new user-friendly and convenient method for the acetylation of N-heteroaryl bromides is described. This process is based on the palladium-catalyzed olefination of an N-heteroaryl bromide with butyl vinyl ether, followed by acid hydrolysis of the intermediate heteroaryl vinyl ether in situ. Isopropanol at 85°C, in the presence of K3PO 4·3H2O (2 equiv), PdCl2 (2 mol%) and (o-tolyl)3P (4 mol%), provided the best conditions, giving yields of N-heteroaryl bromides up to 75%. Georg Thieme Verlag Stuttgart.

DIHYDROPYRIDINONE MGAT2 INHIBITORS FOR USE IN THE TREATMENT OF METABOLIC DISORDERS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d] pyrimidin-4-ylamine: Structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors

4-Amino-5,7-disubstituted pyridopyrimidines are potent, non-nucleoside inhibitors of adenosine kinase (AK). We recently identified a potent, orally efficacious analog, 4 containing a 7-pyridylmorpholine substituted ring system as the key structural element of this template. In this report, we disclose the pharmacologic effects of five- and six-membered heterocyclic ring replacements for the pyridine ring in 4. These replacements were found to have interesting effects on in vivo efficacy and genotoxicity as well as in vitro potency. We discovered that the nitrogen in the heterocyclic ring at C(7) is important for the modulation of mutagenic side effects (Ames assay).