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CAS

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27262-39-1

(S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate, also known as (S)-bupivacaine, is a chemical compound that serves as a long-acting amide-type local anesthetic. It is a salt of the L-tartrate ester of (S)-bupivacaine, which is derived from piperidine and benzoic acid. (S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate works by blocking the transmission of pain signals from nerves to the brain, leading to numbness and loss of sensation in a specific area of the body.

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  • 27262-39-1 Structure

  • Basic information

    1. Product Name: (S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate
    2. Synonyms:
    3. CAS NO:27262-39-1
    4. Molecular Formula:
    5. Molecular Weight: 822.956
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 27262-39-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate(27262-39-1)
    11. EPA Substance Registry System: (S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate(27262-39-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 27262-39-1(Hazardous Substances Data)

27262-39-1 Usage

Uses

Used in Medical and Dental Procedures:
(S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate is used as a local anesthetic for medical and dental procedures, such as surgeries, to provide pain relief and numbness in the affected area. Its long-acting properties make it an ideal choice for procedures that require extended periods of anesthesia.
Used in Pain Management after Surgery:
(S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate is used as a pain management agent after surgery to help control and alleviate postoperative pain. Its long-lasting effects contribute to a more comfortable recovery period for patients.
Used in Chronic Pain Treatment:
(S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate is being studied for its potential in treating chronic pain conditions. Its ability to block pain signals can provide relief for patients suffering from persistent pain.
Used in Epidural Anesthesia:
(S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate is used as a component of epidural anesthesia, a technique that involves injecting the anesthetic into the epidural space of the spinal canal. This method is commonly used during childbirth and certain surgeries to provide pain relief and numbness in the lower body.

Check Digit Verification of cas no

The CAS Registry Mumber 27262-39-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,2,6 and 2 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 27262-39:
(7*2)+(6*7)+(5*2)+(4*6)+(3*2)+(2*3)+(1*9)=111
111 % 10 = 1
So 27262-39-1 is a valid CAS Registry Number.

27262-39-1Downstream Products

27262-39-1Relevant articles and documents

Synthesis, biological evaluation, and molecular docking of ropivacaine analogs as local anesthetic agents

Li, Wen,Ding, Lina,Liu, Hong-Min,You, Qidong

, p. 954 - 965 (2018)

Two series of ropivacaine analogs (4a–4q, 7a–7c) were synthesized, and their biological activities were evaluated as local anesthetic agents. Most of the compounds displayed detectable local anesthetic characteristics. Among them, compound 4l showed significant efficacy with sciatic nerve block, infiltration, corneal surface, and spinal anesthetic activities. It was as potent as the reference compound ropivacaine. Dissociation constants of these compounds were 5.9–7.9. In addition, molecular docking modeling on compound 4l and ropivacaine was performed to delineate structural requirements and potential mechanisms for the local anesthetic activity. This study provides valuable new information for our ongoing endeavor to design more potent local anesthetics.

PROCESS FOR THE PREPARATION OF (S)-ROPIVACAINE HYDROCHLORIDE MONOHYDRATE

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Page/Page column 9, (2009/05/29)

Process for preparation of Ropivacaine hydrochloride monohydrate comprising resolution of racemic pipecoloxylidide in non-ketonic solvents to give (S)-pipecoloxylidide followed by N-propylation to in water ass reaction medium give (S)-Ropivacaine base; co

ROPIVACAINE HYDROCHLORIDE ANHYDRATE AND THE PREPARATION THEREOF

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Page/Page column 9-10, (2008/06/13)

The invention pertains to a process for preparing stable anhydrous Ropivacaine hydrochloride, the process involving preparing Ropivacaine hydrochloride from Ropivacaine base, wherein Ropivacaine base is provided having a chiral purity of more than 95 %, a

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