27305-48-2

Basic information

• Product Name: 1,5-naphthyridine N-(1)-oxide
• Synonyms: 1,5-naphthyridine N-(1)-oxide;1,5-Naphthyridine N-oxide;NSC 364754;1-oxido-1,5-naphthyridin-1-ium
• CAS NO: 27305-48-2
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.14604
• Mol File: 27305-48-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 150-151℃ (hexane )
• Boiling Point: 318.5°Cat760mmHg
• Flash Point: 146.4°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000671mmHg at 25°C
• Refractive Index: 1.64
• PKA: 2.09±0.40(Predicted)
• CAS DataBase Reference: 1,5-naphthyridine N-(1)-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-naphthyridine N-(1)-oxide(27305-48-2)
• EPA Substance Registry System: 1,5-naphthyridine N-(1)-oxide(27305-48-2)

Safety Data

• Hazardous Substances Data: 27305-48-2(Hazardous Substances Data)

Usage

Class

Aromatic heterocyclic compounds

Subclass

Naphthyridines

Type

N-oxide derivative

Structure

Contains an oxygen atom bonded to the nitrogen atom within the naphthyridine ring

Potential applications

Pharmaceutical and agrochemical industries, research and development

Unique properties

Interesting molecule for further study and potential use in various chemical and biological processes

InChI:InChI=1/C8H6N2O/c11-10-6-2-3-7-8(10)4-1-5-9-7/h1-6H

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 254-79-5 1,5-naphthyridine 
• 79-21-0 peracetic acid 
• 64-19-7 acetic acid 

Downstream Products

• 7689-62-5 2-chloro-1,5-naphthyridine 
• 1309774-03-5 7-bromo-2-chloro-1,5-naphthyridine 
• 959616-36-5 7-bromo-1,2-dihydro-1,5-naphthyridin-2-one 
• 51532-07-1 2-bromo-1,5-naphthyridine 
• 17965-71-8 3-bromo-1,5-naphthyridine 
• 1142927-36-3 1,5-naphthyridine-2-carbonitrile 
• 49850-62-6 1,5-naphthyridine-2-carboxylic acid 
• 1201842-52-5 N-(2-chloro-5-(1,5-naphthyridin-4-yl)-3-pyridinyl)-4-fluorobenzenesulfonamide 
• 27392-68-3 4-amino-1,5-naphthyridine 
• 7689-63-6 4-chloro-1,5-naphthyridine 
• 1201842-49-0 N-(2-chloro-5-(1,5-naphthyridin-2-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 10261-82-2 1,5-naphthyridin-2(1H)-one 

Relevant articles and documents

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SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the CXCR4 pathway.