2745-26-8

Basic information

• Product Name: furan-2-acetic acid
• Synonyms: furan-2-acetic acid;2-FURYLACETIC ACID;(Furan-2-yl)acetic acid;2-Furanacetic acid;2-(2-furyl)acetic acid;2-furan-2-ylacetic acid;2-furan-2-ylethanoic acid;2-Furanylacetic acid
• CAS NO: 2745-26-8
• Molecular Formula: C₆H₆O₃
• Molecular Weight: 126.11004
• EINECS: 220-380-3
• Product Categories: Building Blocks;C4 to C7;Chemical Synthesis;Furans;Heterocyclic Building Blocks
• Mol File: 2745-26-8.mol

Chemical Properties

• Melting Point: 64-69℃
• Boiling Point: 234℃
• Flash Point: 95℃
• Appearance: /
• Density: 1.265
• Vapor Pressure: 0.0304mmHg at 25°C
• Refractive Index: 1.5627 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.16±0.10(Predicted)
• CAS DataBase Reference: furan-2-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: furan-2-acetic acid(2745-26-8)
• EPA Substance Registry System: furan-2-acetic acid(2745-26-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 2745-26-8(Hazardous Substances Data)

Usage

Uses

2-(Furan-2-yl)acetic Acid is one of the compounds detected in tobacco smoke condensate.

InChI:InChI=1/C6H6O3/c7-6(8)4-5-2-1-3-9-5/h1-3H,4H2,(H,7,8)

Upstream product

• 15022-16-9 2-(furan-2-yl)acetaldehyde 
• 2745-25-7 2-(furan-2-yl)acetonitrile 
• 1467-70-5 furan-2-yl-oxo-acetic acid 
• 857821-14-8 α-(furan-2-yl)malonic acid 
• 617-88-9 2-Chloromethylfuran 
• 201230-82-2 carbon monoxide 
• 850881-92-4 isopropyl (furan-2-yl)acetate 
• 95530-78-2 7-oxabicyclo[2.2.1]hept-5-en-2-one 
• 65372-09-0 tert-butyl (2-furanyl)acetate 
• 82236-49-5 benzyl 2-(2-furyl)-2-benzylsulfonylacetate 
• 98-00-0 (2-furyl)methyl alcohol 
• 4915-22-4 methyl furan-2-ylacetate 
• 4066-13-1 3-furan-2-yl-2-thioxo-propionic acid 
• 50767-82-3 dimethyl (2-furyl)propanedioate 

Downstream Products

• 4915-22-4 methyl furan-2-ylacetate 
• 4915-21-3 ethyl 2-furanacetate 
• 113986-24-6 2-(furan-2-yl)-N-phenylacetamide 
• 534-22-5 2-methylfuran 
• 2434-00-6 (tetrahydro-furan-2-yl)-acetic acid 
• 2745-27-9 2-(furan-2-yl)acetic acid chloride 
• 10191-24-9 3-hydroxyhexanoic acid 
• 294855-67-7 N-allyl-[2-(3,4-dimethoxyphenethyl)]-2-furan-2-yl-acetamide 
• 4111-54-0 lithium diisopropyl amide 

Relevant articles and documents

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Green method for synthesizing 2-furylglyoxylic acid

The invention provides a green method for synthesizing 2-furylglyoxylic acid, and belongs to the technical field of pharmaceutical chemical processes. The method includes the following steps: (1) adding solvents, furan, chloroacetic acid and Y-type zeolite molecular sieves to a reaction kettle, and carrying out a reaction to obtain 2-furylacetic acid; (2) adding solvents, cobaltosic oxide and 2,2,6,6-tetramethylpiperidine oxide to the obtained 2-furylacetic acid, and injecting oxygen to oxidize the 2-furylacetic acid to obtain the 2-furylglyoxylic acid. The green method for synthesizing the 2-furylglyoxylic acid has the advantages that a raw material used, namely the chloroacetic acid, is cheap and easy to obtain, heterogeneous catalysts, namely the Y-type zeolite molecular sieves and the cobaltosic oxide, are easy to separate and recover and can be recycled, an auxiliary catalyst, namely the 2,2,6,6-tetramethylpiperidine oxide, is beneficial to acceleration and selectivity improvement of oxidation reactions, the oxygen serving as an oxidant is green and environmentally friendly, and accordingly, costs and generated 'three wastes' of the obtained 2-furylglyoxylic acid are greatly reduced; the purity and the yield of the obtained 2-furylglyoxylic acid are respectively higher than 99% and 90%.

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The invention relates to a green method for preparing 2-furosetyl ketone acid. The green method is characterized in that the green method comprises the following steps that 1, 5-60% dilute sulfuric acid and a 10-70% sodium nitrite solution are prepared; 2, recycled low salinity water, a catalyst and 2-acetyl furan are added to a reactor, stirred and heated to 20-90 DEG C, the dilute sulfuric acidis added first, then the sodium nitrite solution is dropped, and the temperature is kept for 0.1-24 h; 3, ethyl acetate is used for extraction for 2-5 times after cooling; 4, the ethyl acetate is usedfor extraction for 2-20 times after adjusting PH to 0.8-1.2 in a water phase, after an organic phase is combined and decompressing distillation is carried out, dichloromethane is added, crystallization is conducted for 4-72 h at the temperature of -40-0 DEG C, and the 2-furosetyl ketone acid is obtained after suction filtration; and 5, pH in the water phase is adjusted to be neutral, crystallization is conducted for 1-72 h at the temperature of -20-20 DEG C, aqueous sodium sulfate is obtained after filtration, and clear liquid is treated by a negative pressure concentrator to obtain recycledwater and the recycled low salinity water. The green method has the advantages that process is simple, and operation is easy; reaction is stable and efficient, side reactions are few, and industrial scale-up production is easy to achieve; and low salt waste water can be recycled and applied to basically achieve no waste water discharge.

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