4915-21-3Relevant academic research and scientific papers
Radical couplings as key steps for the preparation of derivatives of nonactic acid
Loiseau, Francois,Simone, Jean-Mary,Carcache, David,Bobal, Pavel,Neier, Reinhard
, p. 121 - 129 (2007)
Free radical couplings from furan, as cheap starting material, were studied in view of developing a rapid strategy en route to the synthesis of derivatives of nonactin. The chain containing the alcohol function was introduced in one or two steps in 86% yi
Homolytic aromatic substitutions of pentatomic heteroaromatics with electrophilic carbon radicals generated by alkyl halides and triethylborane
Baciocchi,Muraglia
, p. 5015 - 5018 (1993)
An efficient homolytic aromatic substitution of pyrroles, furan and thiophene by ·CH2CO2Et and ·CH(CH3)CO2Et has been carried out the radicals being generated by autoxidation of BEt3 in the presence of XCH2CO2Et and XCH(CH3)CO2Et(X=Br, I).
CIBALACKROT RED DYE COMPOUNDS AND METHODS OF USE IN ORGANIC SOLID-STATE LASERS AND OPTO-ELECTRONIC APPLICATIONS
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Paragraph 00204, (2021/04/10)
Cibalackrot red dye monomer and dimer compounds of formulae (I) and (II) are disclosed as well as combination of the Cibalackrots with host matrices such as a mixed host of mCP and HBT. Use of the Cibalackrots as laser dyes as well in organic solid-state lasers and opto-electronic applications is also described.
Synthesis method of furan acetate compound
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Paragraph 0016, (2021/06/06)
The invention discloses a synthesis method of a furan acetate compound, wherein the synthesis method comprises the steps: by taking a furfuryl alcohol compound as a raw material, carbon monoxide gas as a carbonyl source and an ester compound as an additive, carrying out carbonylation reaction in an organic solvent under the action of a catalyst to obtain the furan acetate compound, wherein the catalyst is a combination of alkali, palladium metal salt and a phosphine-containing ligand. The furfuryl alcohol compound is used as the raw material, the furan acetate compound is synthesized by increasing the carbon number of the furfuryl alcohol compound through carbonylation, the synthesis process is simple, the synthesis condition is mild, the cost is low, the yield of furfuryl acetate is high, and meanwhile conversion and utilization of renewable resource biomass furfuryl alcohol are achieved.
Structure-Odor Correlations in Homologous Series of Mercapto Furans and Mercapto Thiophenes Synthesized by Changing the Structural Motifs of the Key Coffee Odorant Furan-2-ylmethanethiol
Schoenauer, Sebastian,Schieberle, Peter
, p. 4189 - 4199 (2018/05/01)
Furan-2-ylmethanethiol (2-furfurylthiol; 2-FFT, 1) is long-known as a key odorant in roast and ground coffee and was also previously identified in a wide range of thermally treated foods such as meat, bread, and roasted sesame seeds. Its unique coffee-like odor quality elicited at very low concentrations, and the fact that only a very few compounds showing a similar structure have previously been described in foods make 1 a suitable candidate for structure-odor activity studies. To gain insight into the structural features needed to evoke a coffee-like odor at low concentrations, 46 heterocyclic mercaptans and thio ethers were synthesized, 32 of them for the first time, and their odor qualities and odor thresholds were determined. A movement of the mercapto group to the 3-position kept the coffee-like aroma but led to an increase in odor threshold. A separation of the thiol group from the furan ring by an elongation of the carbon side chain caused a loss of the coffee-like odor and also led to an increase in odor thresholds, especially for ω-(furan-2-yl)alkane-1-thiols with six or seven carbon atoms in the side chain. A displacement of the furan ring by a thiophene ring had no significant influence on the odor properties of most of the compounds studied, but the newly synthesized longer-chain 1-(furan-2-yl)- and 1-(thiophene-2-yl)alkane-1-thiols elicited interesting passion fruit-like scents. In total, only 4 out of the 46 compounds also showed a coffee-like odor quality like 1, but none showed a lower odor threshold. Besides the odor attributes, also retention indices, mass spectra, and NMR data of the synthesized compounds were elaborated, which are helpful in possible future identification of these compounds in trace levels in foods or other materials.
Method for producing hematopoietic stem cells using pyrazole compounds
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Page/Page column 185, (2016/01/10)
An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R1 to R8 are as defined in the description).
PYRAZOLE COMPOUNDS HAVING THERAPEUTIC EFFECT ON MULTIPLE MYELOMA
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Paragraph 0273, (2013/10/07)
Novel therapeutic agents for myeloma are provided. A therapeutic agent for multiple myeloma containing a pyrazole compound represented by the formula (1): wherein R1 is C1-C6 alkyl, C1-C6 alkyl substituted with R17, C1-C6 haloalkyl, phenyl, phenyl substituted with a R11's or the like, R2 is a hydrogen atom, C1-C6 alkyl, phenyl or phenyl optionally substituted with e R21's or the like, R3 is a hydrogen atom or the like, X is a single bond or —(CR6, R7)n—, each of R4 and R5 is independently C1-C6 alkyl or the like, R6 and R7 are hydrogen atoms or C1-C6 alkyl, R8 is phenyl, phenyl optionally substituted with k R81's or the like, a tautomer of the compound or a pharmaceutically acceptable salt or solvate thereof, as an active ingredient.
2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS
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Page/Page column 130, (2008/12/05)
The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
Regioselective synthesis of functionalized furans by cyclization of 1,3-bis-silyl enol ethers with 1-chloro-2,2-dimethoxyethane
Bellur, Esen,Goerls, Helmar,Langer, Peter
, p. 2074 - 2090 (2007/10/03)
Cyclization of 1,3-bis-silyl enol ethers with 1-chloro-2,2-dimethoxyethane allowed an efficient, regio- and diastereo-selective synthesis of a variety of 2-alkylidene-4-methoxy-tetrahydrofurans. The TFA-mediated elimination of methanol resulted in the formation of functionalized furans. Simi larly, 2,3,3a,4,5,6-hexahydro-2,3-benzofurans were prepared and transformed into 4,5,6,7-tetrahydro-2,3-benzofurans by treatment with TFA Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
Efficient synthesis of furan-2-ylacetates, 7-(alkoxycarbonyl)benzofurans, and 7-(alkoxycarbonyl)-2,3-dihydrobenzofurans based on cyclization reactions of free and masked dianions: A "cyclization/dehydrogenation" strategy
Bellur, Esen,Langer, Peter
, p. 10013 - 10029 (2007/10/03)
A variety of furan-2-ylacetates have been prepared by dehydrogenation of monocyclic 2-alkylidene-tetrahydrofurans, which are readily available by cyclizations of open-chained 1,3-dicarbonyl dianions with 1-bromo-2- chloroethane. 5′H-[2,3′]Bifuranyl-2′-one
