27512-26-1Relevant articles and documents
Rhodium(II) Acetate-Catalyzed Reaction of 2-Amino-4,5-dihydro-3-furancarbonitriles with Dialkyl Diazomalonates
Yamagata, Kenji,Okabe, Fumi,Yamazaki, Motoyoshi
, p. 562 - 567 (1999)
2-Amino-4,5-dihydro-3-furancarbonitriles 3 react with dialkyl diazomalonates in the presence of rhodium(II) acetate to yield dialkyl (5-amino-4-cyano-2,3-dihydro-3-furanyl)propanedioates 4. Dehydrogenation of 4 with DDQ provided dialkyl (5-amino-4-cyano-3
Preparation method of 3-aminomethyl tetrahydrofuran
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Paragraph 0022; 0023; 0024; 0025; 0026; 0036-0039; 0046-0049, (2017/08/29)
The invention relates to a preparation method of 3-aminomethyl tetrahydrofuran. Specifically the invention relates to a method of preparing 3-aminomethyl tetrahydrofuran through reducing 3-cyano-gamma-butyrolactone. A novel synthesis technology is adopted. Ethyl cyanoacetate and ethylene oxide carry out cyclization reactions under an alkaline condition to obtain 3-cyano-gamma-butyrolactone; then 3-cyano-gamma-butyrolactone is reduced to obtain 2-aminomethyl-1,4-butylene glycol, and finally 2-aminomethyl-1,4-butylene glycol carries out dehydration and cyclization reactions to obtain 3-aminomethyl tetrahydrofuran. The synthesis technology has the advantages of easily available raw materials, simple operation, mild reaction conditions, high yield and product purity, little environmental pollution, and low production cost, is suitable for industrial massive production, and has a wide application prospect.
