27533-32-0

Basic information

• Product Name: 3-aMino-2-naphthaMide
• Synonyms: 3-aMino-2-naphthaMide;2-NaphthalenecarboxaMide, 3-aMino-;3-amino-2-Naphthalenecarboxamide;2-aminonaphthalene-3-carboxamide
• CAS NO: 27533-32-0
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.2099
• EINECS: -0
• Mol File: 27533-32-0.mol

Chemical Properties

• Melting Point: 234-236 °C
• Boiling Point: 410.4±18.0 °C(Predicted)
• Appearance: /
• Density: 1.288±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 16.55±0.30(Predicted)
• CAS DataBase Reference: 3-aMino-2-naphthaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-aMino-2-naphthaMide(27533-32-0)
• EPA Substance Registry System: 3-aMino-2-naphthaMide(27533-32-0)

Safety Data

• Hazardous Substances Data: 27533-32-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-Amino-2-naphthamide is used as a building block in organic synthesis for the creation of various biologically active compounds and pharmaceuticals. Its unique structure allows for the development of a wide range of molecules with potential therapeutic applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Amino-2-naphthamide is utilized as a key intermediate in the synthesis of drugs. Its presence in the molecular structure can contribute to the pharmacological properties of the final product, making it a valuable component in drug discovery and development.
Used in Dye and Pigment Production:
3-Amino-2-naphthamide is also employed in the production of dyes and pigments. Its chemical properties make it suitable for creating a variety of colorants used in different industries, such as textiles, plastics, and printing inks.

Upstream product

• 53653-44-4 2H-Naphtho<2,3-e>-1,3-oxazin-2,4(3H)-dion 
• 5959-52-4 2-Amino-3-naphthoic acid 
• 29753-32-0 2H-naphth<2,3-d><3,1>oxazine-2,4(1H)-dione 

Downstream Products

• 22440-29-5 2-phenylbenzo[g]quinazolin-4(3H)-one 

Relevant articles and documents

From PARP1 to TNKS2 inhibition: A structure-based approach

Tankyrases (TNKSs) have recently gained great consideration as potential targets in Wnt/β-catenin pathway-dependent solid tumors. Previously, we reported the 2-mercaptoquinazolin-4-one MC2050 as a micromolar PARP1 inhibitor. Here we show how the resolution of the X-ray structure of PARP1 in complex with MC2050, combined with the computational investigation of the structural differences between TNKSs and PARP1/2 active sites, provided the rationale for a structure-based drug design campaign that with a limited synthetic effort led to the discovery of the bis-quinazolinone 5 as a picomolar and selective TNKS2 inhibitor, endowed with antiproliferative effects in a colorectal cancer cell line (DLD-1) where the Wnt pathway is constitutively activated.

One-Pot Cascade Synthesis of Quinazolin-4(3H)-ones via Nickel-Catalyzed Dehydrogenative Coupling of o-Aminobenzamides with Alcohols

In this paper, we report a general, efficient, and environmentally benign method for the one-pot cascade synthesis of quinazolin-4(3H)-ones via acceptorless dehydrogenative coupling of o-aminobenzamide with alcohols catalyzed by a simple Ni(II) catalyst, [Ni(MeTAA)], featuring a tetraaza macrocyclic ligand (tetramethyltetraaza[14]annulene (MeTAA)). A wide variety of substituted quinazolin-4(3H)-ones were synthesized in high yields starting from readily available benzyl alcohols and o-aminobenzamides. Several controlled reactions along with deuterium labeling studies were carried out to establish the acceptorless dehydrogenative nature of the reactions.

2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER

Novel pyrrolopyrimidines as shown in formula (I) and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.

Fused pyrimidin-4(3H)-ones as antiallergy agents

Fused heterocyclic ring systems in which a quinoline or a pyridine component is "fused" to a pyrimidine having a 2-methyl, 2-ethyl, or 2-acetyl group and a 4-keto group, and to similar ring systems in which a quinoline, a naphthalene or a pyridine component is "fused" to a pyrimidine having a 2-carboxy group and a 4-keto group, derivatives, and pharmaceutically-acceptable cationic salts thereof, and their use as antiallergy agents, and intermediates therefor.