27550-90-9

Basic information

• Product Name: 2-Methylmorpholine
• Synonyms: 2-METHYLMORPHOLINE HYDROCHLORIDE;2-METHYLMORPHOLINE HCL;2-Methylmorpholine;Morpholine, 2-Methyl-;2-MethylMoupholine;rac 2-Methyl-morpholine, 98%
• CAS NO: 27550-90-9
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Product Categories: pharmacetical;API intermediates
• Mol File: 27550-90-9.mol

Chemical Properties

• Boiling Point: 137.1 °C at 760 mmHg
• Flash Point: 41.3 °C
• Appearance: /
• Density: 0.891 g/cm³
• Vapor Pressure: 0.633mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.01±0.40(Predicted)
• CAS DataBase Reference: 2-Methylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylmorpholine(27550-90-9)
• EPA Substance Registry System: 2-Methylmorpholine(27550-90-9)

Safety Data

• RIDADR: 2920
• PackingGroup: Ⅱ
• Hazardous Substances Data: 27550-90-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Methylmorpholine is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, enhancing the efficiency and selectivity of the processes involved.
Used in Catalyst Production:
In the production of bonding agents, 2-Methylmorpholine serves as a catalyst to accelerate the reaction rates, improving the overall performance and quality of the final products.
Used in Chemical Industry:
2-Methylmorpholine is used as a solvent in the chemical industry for its ability to dissolve a wide range of substances, making it a versatile component in various chemical processes.
Used in Pharmaceutical Industry:
2-Methylmorpholine is utilized in the pharmaceutical industry as an intermediate in the synthesis of active pharmaceutical ingredients, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Methylmorpholine is employed as a component in the formulation of pesticides and other agricultural chemicals, enhancing their effectiveness and performance.
Used in Coatings and Adhesives Industry:
2-Methylmorpholine is used as a catalyst in the production of coatings and adhesives, improving their bonding properties and curing characteristics, which is essential for various applications in construction, automotive, and other industries.

InChI:InChI=1/C5H11NO.ClH/c1-5-4-6-2-3-7-5;/h5-6H,2-4H2,1H3;1H

Upstream product

• 7664-93-9 sulfuric acid 
• 6579-55-1 1-(2-hydroxyethylamino)-2-propanol 
• 127958-63-8 6-methylmorpholin-3-one 

Downstream Products

• 92197-25-6 2-(2-methyl-morpholin-4-yl)-1-phenyl-ethanol 
• 38324-25-3 5,8-bis-(2-methyl-morpholin-4-yl)-2-phenyl-pyrimido[4,5-d]pyridazine 
• 92653-08-2 (2-methyl-morpholin-4-yl)-acetic acid 2-oxo-2-phenyl-ethyl ester 
• 26094-77-9 4-(3-cyclohexyl-acryloyl)-2-methyl-morpholine 
• 19199-40-7 4-[3-(4-chloro-phenyl)-acryloyl]-2-methyl-morpholine 
• 19856-72-5 2-Methyl-4-(3-methoxy-4-acetoxy-cinnamoyl)-morpholin 
• 16562-73-5 4-[3-(4-acetoxy-3,5-dimethoxy-phenyl)-acryloyl]-2-methyl-morpholine 
• 19406-56-5 2-methyl-4-(4-phenyl-but-3-enoyl)-morpholine 
• 56414-81-4 4-(N-benzyloxycarbonyl-valyl)-2-methyl-morpholine 
• 19202-08-5 4-(4-chloro-benzoyl)-2-methyl-morpholine 
• 17077-39-3 2-methyl-4-(3-phenyl-acryloyl)-morpholine 
• 57961-33-8 1,4-bis-(2-methyl-morpholin-4-yl)-7-phenyl-pyrido[3,4-d]pyridazine 
• 16562-66-6 2-Methyl-4-(3.4.5-trimethoxy-cinnamoyl)-morpholin 
• 17077-47-3 2-methyl-4-(3-phenyl-allyl)-morpholine 

Relevant articles and documents

Prediction of structures, properties, and functions of alternating copolymers of ethylene imine and ethylene oxide as an example of molecular design for polymers

Conformational analysis of two alternating copolymers, poly(ethylene imine-alt-ethylene oxide) (PEIEO) and poly(N-methylethylene imine-alt-ethylene oxide) (PMEIEO), has been carried out by the inversional-rotational isomeric state (IRIS) analysis of ab initio molecular orbital (MO) calculations and 1H and 13C NMR experiments for their model compounds. On the basis of the conformational energies derived therefrom and molecular mechanics and MO calculations, higher-order structures, physical properties, and functions of the two copolymers have been predicted as an example of molecular design. These copolymers are expected to form various hydrogen bonds: PEIEO, N-H...O (interaction energy, -1.75 kcal mol-1), C-H...N (-0.68 kcal mol-1), and C-H...O (-0.21 kcal mol-1); PMEIEO, C-H...N (-0.66 kcal mol-1), and C-H...O (-0.41 kcal mol-1). In particular, the N-H...O hydrogen bond of PEIEO is too strong to be broken even by protic solvents such as methanol and water but replaced by an intermolecular N-H...O=S attraction in dimethyl sulfoxide. The C-N and C-O bonds of PEIEO prefer the trans state as found for poly(ethylene imine) (PEI) and poly(ethylene oxide), whereas the C-C bond does not have its own conformational preference and its conformational equilibrium is determined only by the hydrogen bond strength (HBS). The characteristic ratio of PEIEO largely depends on HBS: 1.5 (HBS = 100%); 6.5 (0%). In contrast, the weak hydrogen bonds of PMEIEO little affect the characteristic ratio; 5.2 (HBS = 100%); 5.9 (0%). According to Mattice's analysis (Macromolecules 2004, 37, 4711), PEIEO and PEI tend to form circular paths due to the intramolecular hydrogen bonds. Both molecular mechanics calculations using the Amber force field and density functional MO calculations under the periodic boundary condition have suggested that a double-helical structure may be formed in the PEIEO crystal. The possibility that these copolymers will be utilized as gene carriers and ion conductors is discussed, and the synthetic method is also suggested. In conclusion, these copolymers should be promising and deserve to be synthesized.

INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING

The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.