278598-12-2

Basic information

• Product Name: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE
• Synonyms: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE;Methanone,1-piperidinyl-4-piperidinyl-, hydrochloride (1:1);1-(4-piperidinylcarbonyl)piperidine hydrochloride
• CAS NO: 278598-12-2
• Molecular Formula: C₁₁H₂₀N₂O*ClH
• Molecular Weight: 0
• Mol File: 278598-12-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE(278598-12-2)
• EPA Substance Registry System: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE(278598-12-2)

Safety Data

• Hazardous Substances Data: 278598-12-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE is used as a key intermediate in the synthesis of various drugs, including antihistamines, analgesics, and antidepressants. Its unique structure and reactivity contribute to the development of effective medications for a wide range of health conditions.
Used in Pesticide Production:
In the agricultural sector, PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE is utilized as a component in the manufacturing of pesticides. Its chemical properties make it suitable for creating effective pest control solutions that protect crops and contribute to increased agricultural productivity.
Used in Plasticizer Manufacturing:
PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE is also employed in the production of plasticizers, which are additives used to increase the flexibility and workability of plastics. Its versatility in chemical reactions allows for the creation of plasticizers that enhance the performance of various plastic materials.
Used in Rubber Chemical Production:
In the rubber industry, PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE is used as a component in the manufacturing of rubber chemicals. These chemicals are essential for improving the properties of rubber, such as its elasticity, durability, and resistance to various environmental factors.
It is crucial to handle PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE with care and follow proper safety precautions due to its potential hazards, ensuring the safe and effective use of this valuable chemical compound in various industries.

Upstream product

• 757949-38-5 4-(piperidine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 4968-87-0 piperidin-1-yl(pyridin-4-yl)methanone 

Relevant articles and documents

Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter

To identify selective high-affinity inhibitors of the vesicular acetylcholine transporter (VAChT), we have interposed a carbonyl group between the phenyl and piperidyl groups of the prototypical VAChT ligand vesamicol and its more potent analogues benzovesamicol and 5-aminobenzovesamicol. Of 33 compounds synthesized and tested, 6 display very high affinity for VAChT (K i, 0.25-0.66 nM) and greater than 500-fold selectivity for VAChT over σ1 and σ2 receptors. Twelve compounds have high affinity (Ki, 1.0-10 nM) and good selectivity for VAChT. Furthermore, 3 halogenated compounds, namely, trans-3-[4-(4-fluorobenzoyl) piperidinyl]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (28b) (Ki = 2.7 nM, VAChT/sigma selectivity index = 70), trans-3-[4-(5-iodothienylcarbonyl) piperidinyl]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (28h) (Ki = 0.66 nM, VAChT/sigma selectivity index = 294), and 5-amino-3-[4-(p-fluorobenzoyl) piperidinyl]-2-hydroxy-1,2,3,4,-tetrahydronaphthalene (30b) (Ki = 2.40 nM, VAChT/sigma selectivity index = 410) display moderate to high selectivity for VAChT. These three compounds can be synthesized with the corresponding radioisotopes so as to serve as PET/SPECT probes for imaging the VAChT in vivo.

A highly efficient Pd-C catalytic hydrogenation of pyridine nucleus under mild conditions

A synergistic Pd-C catalytic hydrogenation of 4-pyridinecarboxamides straightforward to 4-piperidinecarboxamide hydrochlorides was developed in the presence of ClCH2CHCl2. It provided a novel strategy for highly efficient hydrogenati

COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES

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