280-13-7

Basic information

• Product Name: 8-oxa-3-azabicyclo[3.2.1]octane
• Synonyms: 8-oxa-3-azabicyclo[3.2.1]octane
• CAS NO: 280-13-7
• Molecular Formula: C₆H₁₁NO
• Molecular Weight: 113.159
• Product Categories: CHIRAL CHEMICALS
• Mol File: 280-13-7.mol

Chemical Properties

• Boiling Point: 176.6°C at 760 mmHg
• Flash Point: 58.6°C
• Appearance: /
• Density: 1.028g/cm³
• Vapor Pressure: 1.09mmHg at 25°C
• Refractive Index: 1.469
• PKA: 9.23±0.20(Predicted)
• CAS DataBase Reference: 8-oxa-3-azabicyclo[3.2.1]octane(CAS DataBase Reference)
• NIST Chemistry Reference: 8-oxa-3-azabicyclo[3.2.1]octane(280-13-7)
• EPA Substance Registry System: 8-oxa-3-azabicyclo[3.2.1]octane(280-13-7)

Safety Data

• Hazardous Substances Data: 280-13-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-Oxa-3-azabicyclo[3.2.1]octane is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its ability to form heterocyclic structures and chiral ligands, which are essential in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 8-Oxa-3-azabicyclo[3.2.1]octane serves as a crucial component in the creation of agrochemicals, leveraging its molecular structure to enhance the effectiveness and selectivity of these compounds in agricultural applications.
Used in Organic Synthesis:
8-Oxa-3-azabicyclo[3.2.1]octane is utilized as a versatile intermediate in organic synthesis, particularly for the formation of heterocyclic compounds and chiral ligands. Its stable and non-reactive nature makes it an ideal candidate for complex organic reactions, contributing to the development of novel chemical entities with potential applications across various industries.

InChI:InChI=1/C6H11NO/c1-2-6-4-7-3-5(1)8-6/h5-7H,1-4H2

Upstream product

• 1472-00-0 cis-2,5-bis(hydroxymethyl)-tetrahydrofuran ditosylate 
• 7664-41-7 ammonia 
• 2144-40-3 cis-2,5-bis(hydroxymethyl)tetrahydrofuran 
• 104-80-3 tetrahydrofuran-2,5-dimethanol 
• 1883-75-6 2,5-bis-(hydroxymethyl)furan 
• 2213-51-6 (furan-2,5-diyl) dimethanamine 

Downstream Products

• 99969-71-8 2-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-ethanol 
• 54745-89-0 3-benzoyl-8-oxa-3-aza-bicyclo[3.2.1]octane 
• 666852-94-4 C₁₇H₂₉N₃O₄ 
• 54746-03-1 2-(8-oxa-3-aza-bicyclo[3.2.1]octane-3-carbonyl)-benzoic acid 
• 1197160-15-8 3-[4-chloro-6-(morpholin-4-yl)-1,3,5-triazin-2-yl]-8-oxa-3-azabicyclo[3.2.1]octane 
• 1144081-74-2 2-chloro-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-thieno[3,2-d]pyrimidine 
• 1198277-93-8 4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 1144080-35-2 6-Chloro-1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine 
• 1233339-96-2 3-{2-(methylsulfanyl)-6-[(methylsulfonyl)methyl]pyrimidin-4-yl}-8-oxa-3-azabicyclo[3.2.1]octane 
• 1198278-01-1 1-methyl-4-[4-(8-oxa-3-azabicyclo[3.2.1]octane-3-carbonyl)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 1226854-18-7 C₂₁H₂₆N₄O₃ 
• 1250867-75-4 3-(2,6-dichloro-5-nitropyrimidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane 
• 1250867-57-2 3-(2-chloro-6-(methylsulfonylmethyl)pyrimidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane 
• 1313026-63-9 5-[9-isopropyl-2-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-9H-purin-6-yl]-pyrazin-2-ylamine 

Relevant articles and documents

Novel route for the synthesis of 8-oxa-3-azabicyclo[3.2.1]octane: One-pot aminocyclization of 2,5-tetrahydrofurandimethanol catalyzed by Pt/NiCuAlOx

2,5-Tetrahydrofurandimethanol (THFDM) was selectively transformed into 8-oxa-3-azabicyclo[3.2.1] octane (OABCO), a valuable building block for the synthesis of bioactive molecules, via one-pot aminocyclization with ammonia catalyzed by Pt/NiCuAlOx. Under optimized conditions (200 °C, 6-16 h, 0.5 MPa hydrogen, 0.4 MPa ammonia), the OABCO yield reached 58% with 100% THFDM conversion.

A PROCESS FOR PRODUCING A TETRAHYDROFURAN COMPOUND COMPRISING AT LEAST TWO AMINE FUNCTIONAL GROUPS

The present invention concerns a process for preparing a tetrahydrofuran compound comprising at least two amine functional groups by reacting a furan compound comprising at least two nitrogen-containing functional groups with hydrogen in the presence of a hydrogenation catalyst.

Substituted benzothiazole amide derivatives

A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A2 receptor system comprising administering a compound of formula 1to a person in need of such treatment.

8-Oxa-3-azabicyclo(3.2.1)octane analgesic compositions and method of alleviating pain in animals

Disclosed are compounds, having the following general formula, which are useful as analgesics in living animals. SPC1 Wherein R is a radical selected from the group consisting of aralkyl, aryl, aminoalkyl, arylalkanoyl, heteroaroyl, alkoxy substituted aroyl, alkenyl (C2 to C4), halogen substituted aralkyl, guanadinoalkyl, halogen substituted aroyl, alkyl substituted aroyl, halogen substituted arylalkanoyl, hexahydrobenzoyl, arylalkenoyl, o- or p-alkyl substituted phenylalkanoyl, alkyl substituted naphthylalkanoyl, alkanoyl (C3 to C20), haloalkyl substituted aroyl, alkoxy substituted aralkyl, heteroaralkyl, anilinocarbonyl, adamantanecarbonyl, arylsulfonyl, carboxyl substituted aroyl, hydroxyl substituted aroyl, alkanoyloxy substituted aroyl, arylglyoxylyl, alicyclic, arylene dicarbonyl-8-oxa-3-azabicyclo(3.2.1)octane, alkylene-8-oxa-3-azabicyclo (3.2.1)octane, alkylene dicarbonyl-8-oxa-3-azabicyclo(3.2.1)octane, and the pharmacologically acceptable acid addition salts thereof.