280749-17-9 Usage
Uses
Used in Pharmaceutical Industry:
A 286982 is used as a therapeutic agent for modulating immune responses and treating conditions related to LFA-1 and ICAM-1 interactions. Its ability to inhibit these interactions can potentially be applied in the treatment of autoimmune diseases, inflammatory disorders, and other conditions where the immune system's response needs to be regulated.
Used in Research Applications:
In the field of research, A 286982 serves as a valuable tool for studying the role of LFA-1 and ICAM-1 interactions in various biological processes. It can be used to investigate the mechanisms underlying immune cell adhesion, migration, and activation, as well as to explore the potential of targeting these interactions for therapeutic purposes.
Used in Drug Development:
A 286982 can be utilized in the development of new drugs targeting LFA-1 and ICAM-1 interactions. Its potent inhibitory activity makes it a promising candidate for the creation of novel therapeutics aimed at treating a range of diseases and conditions related to these interactions.
references
[1]. liu, g., et al., discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. identification of an additional binding pocket based on an anilino diaryl sulfide lead. j med chem, 2000. 43(21): p. 4025-40.[2]. katakai, t., k. habiro, and t. kinashi, dendritic cells regulate high-speed interstitial t cell migration in the lymph node via lfa-1/icam-1. j immunol, 2013. 191(3): p. 1188-99.[3]. keating, s.m., et al., competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. protein sci, 2006. 15(2): p. 290-303.
Check Digit Verification of cas no
The CAS Registry Mumber 280749-17-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,0,7,4 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 280749-17:
(8*2)+(7*8)+(6*0)+(5*7)+(4*4)+(3*9)+(2*1)+(1*7)=159
159 % 10 = 9
So 280749-17-9 is a valid CAS Registry Number.
280749-17-9Relevant articles and documents
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
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Page 38, (2010/02/07)
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead
Liu,Link,Pei,Reilly,Leitza,Nguyen,Marsh,Okasinski,Von Geldern,Ormes,Fowler,Gallatin
, p. 4025 - 4040 (2007/10/03)
The interaction between leukocyte function-associated antigen-1 (LFA-1), a member of the β2-integrin family of adhesion molecules, and intracellular adhesion molecule ICAM-1 (cd54) is thought to play a critical role in the inflammatory process.
