28080-54-8

Basic information

• Product Name: 6-Iodo-3-nitropyridine
• Synonyms: 6-IODO-3-NITROPYRIDINE;5-NITRO-2-IODOPYRIDINE;2-IODO-5-NITROPYRIDINE;2-Iodo-5-nitropyridine 97%
• CAS NO: 28080-54-8
• Molecular Formula: C₅H₃IN₂O₂
• Molecular Weight: 249.99
• Product Categories: C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 28080-54-8.mol

Chemical Properties

• Melting Point: 163-168 °C(lit.)
• Boiling Point: 309.867 °C at 760 mmHg
• Flash Point: 141.203 °C
• Appearance: /
• Density: 2.145 g/cm³
• Vapor Pressure: 0.00114mmHg at 25°C
• Refractive Index: 1.674
• PKA: -2.19±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 6-Iodo-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Iodo-3-nitropyridine(28080-54-8)
• EPA Substance Registry System: 6-Iodo-3-nitropyridine(28080-54-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 28080-54-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Iodo-3-nitropyridine is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
6-Iodo-3-nitropyridine is used as a key intermediate in the production of agrochemicals. Its properties contribute to the creation of effective compounds for agricultural applications, such as pesticides and herbicides.
Used in Chemical Reactions:
6-Iodo-3-nitropyridine is used as a reactant in a wide range of chemical reactions. Its versatility in synthesis processes allows for the creation of diverse compounds with potential applications in various industries.

InChI:InChI=1/C5H3IN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H

Upstream product

• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 4487-59-6 2-bromo-5-nitropyridine 
• 64-17-5 ethanol 
• 147-85-3 L-proline 

Downstream Products

• 29958-12-1 5-amino-2-iodopyridine 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 
• 55403-34-4 1-methyl-4-(5-nitropyridin-2-yl)piperazine 
• 99387-23-2 5-nitro-2-propoxypyridine 
• 1323276-40-9 (S)-1-(2-cyanophenoxy)-2-hydroxy-3-(2-(1-(4-iodopyrdinyl)ureido-3-yl)ethyl)amino propane 
• 462-08-8 pyridin-3-ylamine 
• 89621-27-2 [3]pyridyl-hydroxylamine 
• 1345622-54-9 C₅H₅IN₂O 
• 856358-16-2 N-acetyl-sulfanilic acid-(6-iodo-[3]pyridylamide) 

Relevant articles and documents

Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding iodide

An efficient method for the synthesis of aryl and heteroaryl iodides is described in this study. The reactions of aryl and heteroaryl bromides with potassium iodide proceeded smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding iodides in satisfactory to excellent yields.

Synthesis and cardiac imaging of 18F-ligands selective for β1-adrenoreceptors

A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/ β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribution studies demonstrated uptake of each radiotracers from the blood pool into the myocardium (0.48-0.62% ID/g), lung (0.63-0.97% ID/g), and liver (1.03-1.14% ID/g). Dynamic μPET imaging confirmed the in vivo dissection studies.

A revised synthesis of the antitumour antibiotic L-azatyrosine via 2-iodo-5-methoxypyridine

A revised synthesis of the antitumour antibiotic L-azatyrosine is reported, the main features of which are the unambiguous synthesis of the previously misinterpreted 2-iodo-5-methoxypyridine and subsequent palladium-catalysed coupling with an iodoalanine-derived zinc reagent.