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55403-34-4

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55403-34-4 Usage

General Description

2-(4-Methylpiperazin-1-yl)-5-nitropyridine is a chemical compound with the molecular formula C10H14N4O2. It is a yellow crystalline solid that is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals. 2-(4-Methylpiperazin-1-yl)-5-nitropyridine is known for its high purity and stability, making it an important building block for the production of drugs and other bioactive compounds. It is also used in research and development in the field of medicinal chemistry. Additionally, 2-(4-Methylpiperazin-1-yl)-5-nitropyridine is known for its potential as an antiviral and antibacterial agent, and it is being studied for its therapeutic applications in the treatment of various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 55403-34-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,0 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 55403-34:
(7*5)+(6*5)+(5*4)+(4*0)+(3*3)+(2*3)+(1*4)=104
104 % 10 = 4
So 55403-34-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N4O2/c1-12-4-6-13(7-5-12)10-3-2-9(8-11-10)14(15)16/h2-3,8H,4-7H2,1H3

55403-34-4Relevant articles and documents

Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies

Ding, Ke,Guo, Jing,Lu, Xiaoyun,Wang, Jie,Wang, Zuqin,Xiang, Shuang,Zhang, Zhang,Zhou, Yang

, (2021/12/08)

Tropomyosin receptor kinases A (TrkA) is a potential therapeutic target for the treatment of numerous tumor types and chronic pain. However, most of the reported TrkA inhibitors are ATP competitive pan-Trks inhibitors that lack subtype selectivity. A sele

Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction

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Paragraph 0086-0091; 0098, (2021/05/29)

The invention provides a ligand compound capable of being used for copper catalyzed aryl halide coupling reaction, the ligand compound is a three-class compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group, and the invention also provides a catalytic system for the aryl halide coupling reaction. Thecatalytic system comprises a copper catalyst, a compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group adopted as a ligand, alkali and a solvent, and meanwhile, the invention also provides a system for the aryl halide coupling reaction adopting the catalyst system. The compound containing the 2-(substituted or non-substituted) aminopyridine nitrogen oxygen group can be used as the ligand for the copper catalyzed aryl chloride coupling reaction, and the ligand is stable under a strong alkaline condition and can well maintain catalytic activity when being used for the copper-catalyzed aryl chloride coupling reaction. In addition, the copper catalyst adopting the compound as the ligand can particularly effectively promote coupling of copper catalyzed aryl chloride and various nucleophilic reagents which are difficult to generate under conventional conditions, C-N, C-O and C-S bonds are generated, and numerous useful small molecule compounds are synthesized. Therefore, the aryl halide coupling reaction has a very good large-scale application prospect by adopting the copper catalysis system of the ligand.

5-HETEROARYL SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF

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Paragraph 0727; 0728, (2019/09/06)

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, Darier's disease, scleroderma, cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

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