28217-97-2

Basic information

• Product Name: CHLOROMETHIURON
• Synonyms: CHLORMETHIURON;CGA 13444;N'-（4-chloro-2-methylphenyl)-N,N-dimethyl thiourea;Trimethocarbam;Trimethothiocarbam
• CAS NO: 28217-97-2
• Molecular Formula: C₁₀H₁₃ClN₂S
• Molecular Weight: 228.746
• EINECS: 221-912-7
• Mol File: 28217-97-2.mol

Chemical Properties

• Boiling Point: 297.3°Cat760mmHg
• Flash Point: 133.6°C
• Appearance: /
• Density: 1.254g/cm³
• Vapor Pressure: 0.00136mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: CHLOROMETHIURON(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROMETHIURON(28217-97-2)
• EPA Substance Registry System: CHLOROMETHIURON(28217-97-2)

Safety Data

• Hazardous Substances Data: 28217-97-2(Hazardous Substances Data)

Usage

Uses

Chlormethiuron is used as a pesticide. An acaricide.

InChI:InChI=1/C10H13ClN2S/c1-7-6-8(11)4-5-9(7)12-10(14)13(2)3/h4-6H,1-3H3,(H,12,14)

Upstream product

• 23165-53-9 4-chloro-2-methylphenyl isothiocyanate 
• 124-40-3 dimethyl amine 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 67-66-3 chloroform 

Relevant articles and documents

Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur

A copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur in the absence of organophosphine has been established. This approach represents a simple and efficient one-pot synthesis of isothiocyanates, and features excellent functional group tolerance and the use of a cheap, safe and odorless sulfur source. Moreover, this process could directly provide isothiocyanate analogous bioactive molecules, thiocarbonyl-containing pesticides and facile construction of benzoxazole and benzimidazole frames.

Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines

The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o-phenylenediamines are converted to thiocarbamoyl fluorides, isothiocyanates, and difluoromethylthiolated heterocycles, respectively. Thiocarbamoyl fluorides were further transformed into trifluoromethylated amines by using a one-pot process. Thiocarbonyl fluoride is generated in situ and is rapidly fully converted in one pot under mild conditions; therefore, no special safety precautions are needed.

Thiocarbonyl Surrogate via Combination of Sulfur and Chloroform for Thiocarbamide and Oxazolidinethione Construction

An efficient and practical thiocarbonyl surrogate via combination of sulfur and chloroform has been developed. A variety of thiocarbamides and oxazolidinethiones have been established, including chiral thiourea catalysts and chiral oxazolidinethione auxiliaries with high selectivity. Meanwhile, pesticides Diafenthiuron (an acaricide), ANTU (a rodenticide), and Chloromethiuron (an insecticide) were practically synthesized through this method in gram scale. Dicholorocarbene, as the key intermediate, was further confirmed via a carbene-trapping control experiment.