28249-77-6

Basic information

• Product Name: Thiobencarb
• Synonyms: TOBOSA;(s-(4-chlorobenzyl)n,n-diethylthiolcarbamate);B 3015;b-3015;bolero8ec;Carbamic acid, diethylthio-, S-(p-chlorobenzyl) ester;Carbamothioic acid, diethyl-, S-[(4-chlorophenyl)methyl] ester;diethyl-carbamothioicacid,s-((4-chlorophenyl)methyl)ester
• CAS NO: 28249-77-6
• Molecular Formula: C₁₂H₁₆ClNOS
• Molecular Weight: 257.78
• EINECS: 248-924-5
• Product Categories: HERBICIDE;TF - TOPesticides&Metabolites;Alpha sort;Herbicides;Pesticides&Metabolites;Q-ZAlphabetic;Thiocarbamates
• Mol File: 28249-77-6.mol

Chemical Properties

• Melting Point: 1.7°C
• Boiling Point: 126-129°C
• Flash Point: 165.767 °C
• Appearance: Pale yellow/Liquid
• Density: 1.0756 (rough estimate)
• Vapor Pressure: 4.38E-05mmHg at 25°C
• Refractive Index: 1.5630 (estimate)
• Storage Temp.: APPROX 4°C
• PKA: -1.26±0.70(Predicted)
• Water Solubility: 30mg/L(22 oC)
• BRN: 1968440
• CAS DataBase Reference: Thiobencarb(CAS DataBase Reference)
• NIST Chemistry Reference: Thiobencarb(28249-77-6)
• EPA Substance Registry System: Thiobencarb(28249-77-6)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 22-50/53
• Safety Statements: 60-61
• RIDADR: UN 3082
• WGK Germany: 3
• RTECS: EZ7260000
• Hazardous Substances Data: 28249-77-6(Hazardous Substances Data)

Usage

Uses

Used in Agriculture:
Thiobencarb is used as a thiocarbamate herbicide for controlling sedges and grasses in rice paddies. Its application helps to manage unwanted plant growth, ensuring a healthier and more productive rice crop.

Air & Water Reactions

Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.

Reactivity Profile

Thiobencarb is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.

Hazard

Toxic.

InChI:InChI=1/C12H16ClNOS/c1-3-14(4-2)12(15)16-9-10-5-7-11(13)8-6-10/h5-8H,3-4,9H2,1-2H3

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 22318-01-0 diethylamonium N,N'-dimethylmonothiocarbamate 
• 463-58-1 carbon oxide sulfide 
• 109-89-7 diethylamine 
• 201230-82-2 carbon monoxide 
• 534572-34-4 trichlorothioacetic acid S-(4-chlorobenzyl) ester 
• 2430-00-4 2,2,2-trichloro-N,N-diethylacetamide 
• 6258-66-8 (4-chlorophenyl)methanethiol 

Downstream Products

• 75-04-7 ethylamine 
• 51954-76-8 thiobencarb sulfoxide 
• 39918-94-0 S-(4-chlorobenzyl) ethylthiocarbamate 
• 50586-77-1 S-(4-chlorobenzyl) acetyl(ethyl)thiocarbamate 
• 104-88-1 4-chlorobenzaldehyde 
• 6258-66-8 (4-chlorophenyl)methanethiol 
• 873-76-7 para-Chlorobenzyl alcohol 

Relevant articles and documents

Solvent-assisted thiocarboxylation of amines and alcohols with carbon monoxide and sulfur under mild conditions

DMSO or DMF as a solvent strongly accelerated the thiocarboxylation of amines and alcohols with carbon monoxide and sulfur. Under mild conditions (1 atm, 20°C), this thiocarboxylation of amines assisted by DMSO with carbon monoxide and sulfur has been developed into a practical and convenient synthetic method for S-alkyl thiocarbamates in good to excellent yields, including EPTC, thiobencarb, orbencarb, and molinate (herbicides). DMF also showed the similar solvent effect. NMP slightly decreased the effect for the thiocarboxylation of amines, and the yield of S-alkyl thiocarbamate was lowered in DMAc. Surprisingly, no formation of S-alkyl thiocarbamate was observed at the use of the other solvents, such as THF, hexane, toluene, AcOEt, MeCN, MeOH, and H 2O. The present solvent-assisted thiocarboxylation with carbon monoxide and sulfur could be also applied to a new synthesis of S-alkyl O-alkyl carbonothioates from alcohols under mild conditions (1 atm, 20°C) in DMF using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene).

Practical synthesis of S-alkyl thiocarbamate herbicides by carbonylation of amines with carbon monoxide and sulfur

An industrial and economic carbonylation of amines with carbon monoxide and sulfur has been developed for the synthesis of S-alkyl thiocarbamate herbicides. In the presence of potassium carbonate and solvent DMSO, S-alkyl thiocarbamates, such as thiobencarb and orbencarb (herbicides) are synthesized in excellent yields from amines, carbon monoxide, sulfur, and alkyl halides under mild conditions (1atm, 20°C).

Facile one-pot synthesis of S-alkyl thiocarbamates

We report a novel one-pot two-step synthesis of a variety of S-alkyl thiocarbamates. This method offers a two-directional approach making use of trichloroacetyl chloride, requires no complex starting material, incorporates a variety of substituents, and proceeds in high yields.

Facile S-alkyl thiocarbamate synthesis by a novel DBU-assisted carbonylation of amines with carbon monoxide and sulfur

A novel DBU-assisted carbonylation of amines with carbon monoxide and sulfur has been developed for the synthesis of S-alkyl thiocarbamates. In the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene), S-alkyl thiocarbamates are synthesized in excellent yields from amines, carbon monoxide, sulfur, and alkyl halides under mild conditions (1 atm, 20°C). In the absence of DBU, however, no formation of S-alkyl thiocarbamate is observed. The present DBU-assisted carbonylation can also be applied to new synthetic methods for benthiocarb and orthobencarb (herbicides) and carbamoyl chlorides.

Synergistic herbicidal mixtures

PCT No. PCT/EP96/04935 Sec. 371 Date May 1, 1998 Sec. 102(e) Date May 1, 1998 PCT Filed Nov. 12, 1996 PCT Pub. No. WO97/17852 PCT Pub. Date May 22, 1997A synergistically active herbicidal composition which comprises, as active components, a mixture of 1-(3-chloro-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyridin-2-yl)-5-(methylpropargylamino)-4-pyrazolylcarbonitrile [Component (A)] and a herbicide selected from the group consisting of bentazone, molinate, daimuron, thiobencarb, butachlor, pretilachlor, dimepiperate, fenoxaprop-ethyl, clomeprop, cinmethylin, bromobutide, quinclorac, mefenacet, pyrazosulfuron-ethyl, esprocarb, cinosulfuron, thenylchlor, cumyluron, MK 243, naproanilide, anilofos, benfuresate, bifenox, CH-900, MCPA, nitrofen, oxadiazon, pendimethalin, simetryn, sulcotrione (ICIA0051), trifluralin, piperophos, pyributicarb, ethoxysulfuron, bensulfuronmethyl, pyrazolate, pyrazoxyfen, benzofenap, cyclosulfamuron, cyhalofop-butyl, NBA-061, azimsulfuron, propanil or imazosulfuron [Component (B)] and which are suitable for controlling undesirable plants in rice cultivation.

Herbicidal mixtures having a synergistic effect

PCT No. PCT/EP96/03996 Sec. 371 Date Feb. 17, 1998 Sec. 102(e) Date Feb. 17, 1998 PCT Filed Sep. 12, 1996 PCT Pub. No. WO97/10714 PCT Pub. Date Mar. 27, 1997A composition comprising at least one sulfonylurea of the formula I wherein R1 is substituted alkyl; halogen; a group ER6 (E=O, S or NR7); COOR8; NO2; S(O)oR9; SO2NR10R11; or CONR10R11; R2 is hydrogen, alkyl, alkenyl, alkynyl, halogen, alkoxy, haloalkoxy, haloalkyl, alkylsulfonyl, nitro, cyano or alkylthio; R3 is F, CF3, CF2Cl, CF2H, OCF3, OCF2Cl, or, if R1 is CO2CH3 and R2 is simultaneously fluorine, R3 is Cl, or, if R1 is CH2CF3 or CF2CF3, R3 is methyl, or, if R4 is OCF3 or OCF2Cl, R3 is OCF2H or OCF2Br; R4 is alkoxy, alkyl, alkylthio, alkylamino, dialkylamino, halogen, haloalkyl or haloalkoxy; and R5 is hydrogen, alkoxy or alkyl; or an enviromentally compatible salt of I, and an aryloxyalkanoic acid selected from the group consisting of 2,4-D, 2,4-DB, clomeprop, dichlorprop, dichlorprop-P, dichlorprop-P (2,4-DP-P), fenoprop (2,4,5-TP), fluoroxypyr, MCPA, MCPB, mecoprop, mecoprop-P, napropamide, napropanilide, triclopyr, and an enviromentally compatible salt thereof exhibits a synergistic herbicidal effect.

Agrochemical formulations for water surface application

New agrochemical formulations for application to the water of paddy fields, which formulations comprise A) at least one solid core material having an apparent specific density of less than 1 and a particle diameter within the range from about 300 μm to about 1,400 μm, and B) a coating layer comprising at least one biologically active compound, at least one substance having the ability to reduce the interfacial tension between water and air, at least one oily substance and, if appropriate, one or more additives, and the use of such agrochemical formulations for applying biologically active compounds to the water of paddy fields.

Sulphonylaminophenyluracil herbicides for paddy field

A herbicide for paddy field comprising sulphonylaminophenyluracil derivative as an active ingredient which is represented by the formula (I): STR1 wherein R1 represents hydrogen or methyl, R2 represents C1-5 alkyl, fluro-substituted C1-2 alkyl or C3-6 cycloalkyl, optionally applied in combination with another herbicide.

Herbicidal tetrazolinones

Novel herbicidal tetrazolinones of the formula STR1 wherein Y is hydrogen, bromine or methyl, R1 is ethyl or n-propyl, and R2 is cyclopentyl or cyclohexyl, with the proviso that the total number of carbon atoms in R1 and R2 is 7 or 8. The new tetrazolinones may be mixed with other herbicides.

Triazolecarboxamide herbicides

Compounds of the formula: STR1 wherein X is O or S; R and R1 are substituted or unsubstituted alkyl, alkenyl, alkynyl or cycloalkyl or R and R1 may be joined to form a heterocyclic ring; R2 is substituted or unsubstituted cycloalkyl; and n is 0, 1 or 2 are disclosed as well as their postemergence and preemergence selective herbicide use against both monocot and dicot weeds in crops such as sugarbeets, cotton, soybeans and rice.