28860-09-5 Usage
Description
N-Ethyl 3-Nitrobenzenesulfonamide is a chemical compound that belongs to the class of sulfonamides, characterized by the presence of a nitro group and an ethyl substituent on the benzene ring. It is recognized for its versatile applications in various industries, primarily as a starting material in the synthesis of pharmaceuticals and agrochemicals. Its chemical structure and reactivity make it a valuable intermediate in the production of dyes, pigments, corrosion inhibitors, and other chemical substances. Furthermore, it has demonstrated potential as an anti-inflammatory agent and is being studied for its therapeutic applications in treating various diseases.
Uses
Used in Pharmaceutical and Agrochemical Industries:
N-Ethyl 3-Nitrobenzenesulfonamide is used as a starting material for the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure and reactivity make it a valuable component in the development of new drugs and pesticides.
Used in Dye and Pigment Production:
N-Ethyl 3-Nitrobenzenesulfonamide is identified as a potential intermediate in the production of dyes and pigments. Its chemical properties contribute to the color and stability of these products, making it an essential component in the manufacturing process.
Used in Corrosion Inhibition:
N-Ethyl 3-Nitrobenzenesulfonamide is known for its use in the production of corrosion inhibitors. Its chemical properties help to prevent the degradation of materials, particularly in industrial applications where corrosion can lead to significant losses.
Used as a Building Block in Chemical Synthesis:
N-Ethyl 3-Nitrobenzenesulfonamide serves as a building block in the manufacturing of other chemical substances. Its versatile chemical structure allows it to be incorporated into a wide range of compounds, enhancing their properties and applications.
Used in Anti-Inflammatory Applications:
N-Ethyl 3-Nitrobenzenesulfonamide has shown potential as an anti-inflammatory agent. It is being studied for its potential use in the treatment of various diseases, particularly those involving inflammation. Its precise applications and uses in this area are dependent on its specific properties and chemical reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 28860-09-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,8,6 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 28860-09:
(7*2)+(6*8)+(5*8)+(4*6)+(3*0)+(2*0)+(1*9)=135
135 % 10 = 5
So 28860-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O4S/c1-2-9-15(13,14)8-5-3-4-7(6-8)10(11)12/h3-6,9H,2H2,1H3
28860-09-5Relevant articles and documents
Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors
Lawrence, Harshani R.,Kazi, Aslamuzzaman,Luo, Yunting,Kendig, Robert,Ge, Yiyu,Jain, Sanjula,Daniel, Kenyon,Santiago, Daniel,Guida, Wayne C.,Sebti, Said M.
experimental part, p. 5576 - 5592 (2010/09/15)
Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.
