28900-64-3 Usage
Description
2,3-Dihydroxy-L-Phenylalanine, commonly known as L-DOPA, is a naturally occurring amino acid that serves as a chemical precursor in the synthesis of neurotransmitters such as dopamine, norepinephrine, and epinephrine. It is characterized by its unique chemical structure, featuring a phenylalanine molecule with hydroxyl groups added to the 3 and 4 positions of the benzene ring, which endows it with distinctive properties and biological activity. L-DOPA is found in certain dietary sources, including broad beans, fava beans, and the seeds and leaves of Mucuna pruriens, a tropical legume.
Uses
Used in Pharmaceutical Industry:
2,3-Dihydroxy-L-Phenylalanine is used as a medication for the treatment of Parkinson's disease and dopamine-responsive dystonia. Its ability to cross the blood-brain barrier and be converted into dopamine makes it an effective treatment for these conditions.
Used in Neurological Disorders Treatment:
L-DOPA is used as a therapeutic agent for neurological disorders such as depression, schizophrenia, and ADHD. Its potential in these areas is supported by ongoing research and clinical studies.
Used in Dietary Supplements:
2,3-Dihydroxy-L-Phenylalanine is used as a dietary supplement in certain foods, particularly those rich in L-DOPA, such as broad beans, fava beans, and Mucuna pruriens. These dietary sources contribute to the body's production of neurotransmitters and support overall brain health.
Check Digit Verification of cas no
The CAS Registry Mumber 28900-64-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,9,0 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 28900-64:
(7*2)+(6*8)+(5*9)+(4*0)+(3*0)+(2*6)+(1*4)=123
123 % 10 = 3
So 28900-64-3 is a valid CAS Registry Number.
28900-64-3Relevant articles and documents
Enantiomeric analysis of pharmaceutical compounds by Ion/molecule reactions
Grigorean,Lebrilla
, p. 1684 - 1691 (2007/10/03)
Protonated complexes involving cyclodextrin hosts and guest compounds that are pharmacologically important are produced in the gas phase and reacted with a gaseous amine. The guest is exchanged to produce a new protonated complex with the amine. The reaction is enantioselective and is used to develop a method for determining enantiomeric excess using only mass spectrometry. The pharmaceutical compounds include DOPA, amphetamine, ephedrine, and penicillamine. The presence of more than one reacting species is observed with DOPA and penicillamine. Molecular dynamics calculations are used to understand the nature of the interactions and the possible source of the variations in the reactivities.
