29198-86-5

Basic information

• Product Name: 3-(1,3-BENZOTHIAZOL-2-YL)PROPANOIC ACID
• Synonyms: 2-Benzothiazolepropanoicacid(9CI);3-(1,3-benzothiazol-2-yl)propanoic acid(SALTDATA: FREE);2-(2-Carboxyethyl)-1,3-benzothiazole;3-(Benzo[d]thiazol-2-yl)propanoic acid;3-(1,3-benzothiazol-2-yl)propionic acid
• CAS NO: 29198-86-5
• Molecular Formula: C10H9NO2S
• Molecular Weight: 207.2527
• Product Categories: BENZOTHIAZOLE
• Mol File: 29198-86-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 393.5°Cat760mmHg
• Flash Point: 191.8°C
• Appearance: /
• Density: 1.379g/cm³
• Vapor Pressure: 6.71E-07mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(1,3-BENZOTHIAZOL-2-YL)PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-BENZOTHIAZOL-2-YL)PROPANOIC ACID(29198-86-5)
• EPA Substance Registry System: 3-(1,3-BENZOTHIAZOL-2-YL)PROPANOIC ACID(29198-86-5)

Safety Data

• Hazardous Substances Data: 29198-86-5(Hazardous Substances Data)

Usage

General Description

3-(1,3-benzothiazol-2-yl)propanoic acid is a chemical compound with the molecular formula C11H9NO2S. It is a derivative of benzothiazole, which is a heterocyclic compound containing sulfur and nitrogen atoms in its ring structure. 3-(1,3-BENZOTHIAZOL-2-YL)PROPANOIC ACID is used in the pharmaceutical industry as a starting material for the synthesis of various drugs, particularly non-steroidal anti-inflammatory drugs (NSAIDs) such as etodolac. It has anti-inflammatory and analgesic properties, making it useful for the treatment of conditions such as arthritis and other inflammatory disorders. Additionally, the benzothiazole moiety in the compound has been linked to potential biological activities, making it a subject of interest in medicinal chemistry and drug development.

InChI:InChI=1/C10H9NO2S/c12-10(13)6-5-9-11-7-3-1-2-4-8(7)14-9/h1-4H,5-6H2,(H,12,13)/p-1

Upstream product

• 108-30-5 succinic acid anhydride 
• 137-07-5 2-amino-benzenethiol 
• 83-25-0 N-phenylmaleimide 
• 110-15-6 succinic acid 
• 1156151-44-8 C₆H₁₁NO₄ 
• 5430-83-1 N-phenyl-succinamic acid methyl ester 
• 4938-01-6 succinic acid monochloride 
• 33384-33-7 N-phenyl-4-thio-succinamic acid 

Downstream Products

• 610277-15-1 3-benzothiazol-2-yl-propionic acid methyl ester 
• 3973-09-9 3-(benzo[d]thiazol-2-yl)propan-1-ol 
• 1430100-84-7 6-[3-(1,3-benzothiazol-2-yl)propanoyl]-4-(4-fluorobenzyl)-5,6,7,8-tetrahydropyrido-[4,3-d]pyrimidine 

Relevant articles and documents

An efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activities

A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated for in?vitro cytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. The biological evaluation results show that 23, 26 and 29 exhibit better activity against HepG2 and HeLa cancer cell lines. Compound 23 also showed good activity against A549, and A498 cancer cell lines. The analogs were further performed molecular docking studies against human cytochrome P450 2C8 monooxygenase enzyme, calculated some theoretical quantum parameters, ADMET descriptor and molecular electrostatic potential analysis. The strategy applied in this research work may act as a perspective for the rational design of potential anticancer drugs. Communicated by Ramaswamy H. Sarma.

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

DERIVATIVES OF AZA ADAMANTANE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.