304-54-1

Basic information

• Product Name: (+/-)-alpha-methyltryptamine
• Synonyms: ALPHA-METHYLTRYPTAMINE;(+-)-alpha-Methyl-1H-indole-3-ethanamine;1H-Indole-3-ethanamine, alpha-methyl-, (+-)- (9ci)
• CAS NO: 304-54-1
• Molecular Formula: C11H14N2
• Molecular Weight: 174.24
• Mol File: 304-54-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+/-)-alpha-methyltryptamine(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-alpha-methyltryptamine(304-54-1)
• EPA Substance Registry System: (+/-)-alpha-methyltryptamine(304-54-1)

Safety Data

• Hazardous Substances Data: 304-54-1(Hazardous Substances Data)

Upstream product

• 4771-72-6 α-methyl-β-(3-indolyl)-1-nitroethane 
• 22693-51-2 3-(2-nitroprop-1-en-1-yl)-1H-indole 
• 299-26-3 1-(1H-indol-3-yl)propan-2-amine 
• 371-27-7 2,2,2-trifluoroethylbutyrate 
• 61535-48-6 C₂₆H₂₆N₂O₅S 
• 61587-85-7 (S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propyl 4-methylbenzenesulfonate 
• 615-36-1 2-bromoaniline 
• 847199-90-0 tert-butyl (R)-(1-(1H-indol-3-yl)propan-2-yl)carbamate 
• 1384127-07-4 N-octanoyl dimethyl glycine trifluoroethyl ester 
• 1100753-75-0 N-octanoylglycine 2,2,2-trifluoroethyl ester 
• 1039646-91-7 2,3-bis(4-methylbenzoic acid)succinic acid 
• 1201-26-9 3-(1H-indolyl)acetone 
• 113997-61-8 (S,R)-N-α-phenetyl-1-indol-3-yl-2-aminopropane 
• 113997-58-3 (R)-1-(1H-indol-3-yl)-N-((R)-1-phenylethyl)propan-2-amine 

Downstream Products

• 1292798-84-5 (R)-N-[1-(1H-indol-3-yl)propan-2-yl]-2-methoxyacetamide 
• 7795-51-9 (+)-alpha-Methyltryptamine 
• 7795-52-0 (-)-alpha-Methyltryptamine 
• 1193314-21-4 (1R,3S)-5'-chloro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one 
• 1612181-94-8 6-(3-chloro-2-methylphenyl)-4-N-[1-(1H-indol-3-yl)propan-2-yl]pyrimidine-2,4-diamine 
• 86995-94-0 1-Indolyl-3-isopropylmethylpropargylamine 

Relevant articles and documents

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Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet-Spengler Condensation

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A Br?nsted acid catalyzed, operationally simple, scalable route to several functionalized α-(3-indolyl) ketones has been developed and the long-standing regioisomeric issue has been eliminated by choosing appropriate carbonyls. A readily available and cheap bottle reagent was used as the catalyst. This protocol was also applicable to the synthesis of densely functionalized α-(3-pyrrolyl) ketones. A detailed mechanistic study confirmed the involvement of enolether as a reaction intermediate. Several postsynthetic modifications along with easy access to β-carboline, tryptamines, tryptophols, and spiro-indolenine proclaim the synthetic utility of this powerful building block. On the basis of this concept, functionalized carbazoles were constructed by a cascade annulation strategy.