305790-48-1

Basic information

• Product Name: 6-broMo-1-Methyl-1H-benzo[d]iMidazol-2(3H)-one
• Synonyms: 6-broMo-1-Methyl-1H-benzo[d]iMidazol-2(3H)-one;6-bromo-1-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one
• CAS NO: 305790-48-1
• Molecular Formula: C₈H₇BrN₂O
• Molecular Weight: 227.05798
• Mol File: 305790-48-1.mol

Chemical Properties

• Appearance: /
• Density: 1.641±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.21±0.30(Predicted)
• CAS DataBase Reference: 6-broMo-1-Methyl-1H-benzo[d]iMidazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-broMo-1-Methyl-1H-benzo[d]iMidazol-2(3H)-one(305790-48-1)
• EPA Substance Registry System: 6-broMo-1-Methyl-1H-benzo[d]iMidazol-2(3H)-one(305790-48-1)

Safety Data

• Hazardous Substances Data: 305790-48-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one is used as a key intermediate in the synthesis of various pharmaceuticals for its potential medicinal properties. It contributes to the development of new drugs by providing a structural foundation that can be further modified to enhance therapeutic effects.
Used in Research and Development:
In the field of research and development, 6-bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one is utilized as a starting material for the creation of novel chemical entities. Its unique structure allows researchers to investigate its potential applications in various areas of medicine, including the treatment of diseases and the development of new therapeutic agents.
Used in Drug Synthesis:
6-Bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one is employed as a building block in drug synthesis, enabling the production of a wide range of pharmaceutical compounds. Its versatility and stability make it an ideal candidate for the development of new drugs with improved efficacy and safety profiles.
Used in Medicinal Chemistry:
In medicinal chemistry, 6-bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one is used as a structural component in the design and synthesis of new molecules with potential therapeutic applications. Its presence in a molecule can influence its pharmacological properties, making it a valuable tool for the development of innovative treatments.
Used in Drug Discovery:
6-Bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one plays a crucial role in drug discovery, where it is used to identify and optimize compounds with potential therapeutic benefits. Its unique chemical properties allow researchers to explore its interactions with biological targets, leading to the discovery of new drugs with improved efficacy and selectivity.
Used in Chemical Research:
In the realm of chemical research, 6-bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one is employed as a subject of study to understand its reactivity, stability, and potential applications in various chemical processes. This knowledge can be applied to develop new synthetic routes and improve existing methods for the production of pharmaceuticals and other chemical products.

Upstream product

• 337915-79-4 4-bromo-N²-methylbenzene-1,2-diamine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 93933-49-4 2-amino-4-bromobenzenethiol 
• 302800-13-1 5-bromo-N-methyl-2-nitroaniline 
• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 530-62-1 1,1'-carbonyldiimidazole 
• 77-78-1 dimethyl sulfate 
• 161468-56-0 5-Bromo-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 305790-47-0 5-bromo-3-methyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 305790-49-2 1-benzyl-6-(3-chloro-phenyl)-1,3-dihydro-benzoimidazol-2-one 
• 1359757-39-3 1-(2,2-dimethylpropyl)-3-methyl-5-phenyl-1,3-dihydro-2H-benzimidazol-2-one 
• 1359759-14-0 1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one 
• 1359759-42-4 2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]phenoxy}nicotinonitrile 
• 1359759-81-1 1-(2,2-dimethylpropyl)-5-{3-[(2-fluorobenzyl)oxy]phenyl}-3-methyl-1,3-dihydro-2H-benzimidazol-2-one 
• 1359759-86-6 4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]phenoxy}benzonitrile 
• 1359759-96-8 4-({6-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]pyridin-2-yl}oxy)benzonitrile 
• 1378947-22-8 6-bromo-2-chloro-1-methyl-1H-benzo[d]imidazole 

Relevant articles and documents

STAT DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

MDM2 DEGRADERS AND USES THEREOF

The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.

MERTK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

PROTEIN DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.

CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.