312623-79-3

Basic information

• Product Name: 4 6-O-(4-METHOXYBENZYLIDENE)-D-GLUCAL
• Synonyms: 4,6-O-p-Methoxylbenzylidene-D-glucal;4,6-O-(4-Methoxybenzylidene)-D-glucal,97%;D-arabino-Hex-1-enitol, 1,5-anhydro-2-deoxy-4,6-O-[(4-methoxyphenyl)methylene]-;(4aR,8R,8aS)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-ol
• CAS NO: 312623-79-3
• Molecular Formula: C₁₄H₁₆O₅
• Molecular Weight: 264.27
• Mol File: 312623-79-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 120-138 °C(lit.)
• Boiling Point: 276-289 °C(lit.)
• Appearance: /
• CAS DataBase Reference: 4 6-O-(4-METHOXYBENZYLIDENE)-D-GLUCAL(CAS DataBase Reference)
• NIST Chemistry Reference: 4 6-O-(4-METHOXYBENZYLIDENE)-D-GLUCAL(312623-79-3)
• EPA Substance Registry System: 4 6-O-(4-METHOXYBENZYLIDENE)-D-GLUCAL(312623-79-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 312623-79-3(Hazardous Substances Data)

Usage

Uses

4,6-O-(4-Methoxybenzylidene)-D-glucal is used as pharmaceutical intermediate.

Upstream product

• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 13265-84-4 D-glucal 
• 2403-58-9 4-methoxybenzaldehyde diethylacetal 
• 2873-29-2 D-glucal triacetate 

Downstream Products

• 947305-42-2 C₁₅H₁₈O₅ 
• 384346-91-2 3-O-tert-butyldimethylsilyl-4,6-O-(4-methoxybenzylidene)-D-(-)-glucal 

Relevant articles and documents

Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity

Spliceostatin A is a potent inhibitor of spliceosomes and exhibits excellent anticancer activity against multiple human cancer cell lines. We describe here the design and synthesis of a stable cyclopropane derivative of spliceostatin A. The synthesis invo

METHOD OF FORMING OSELTAMIVIR AND DERIVATIVES THEREOF

A process is provided for the synthesis of 4,5-diamino cyclohexene carboxylate ester (1): or a pharmaceutically acceptable salt thereof. R1 - R3 are a silyl-, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. R4, R11 and R12 are H, a silyl-group, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. 3,4-Dihydropyran compound (9): with R5 and R6 being suitable protecting groups, is reacted to form aldehyde (4): which is oxidized and converted to N-substituted carbamate (3): with R7 being a suitable protecting group. (3) is, via oxazolinidone (13): converted to azido carboxylate ester (2): and then to 4,5-diamino cyclohexene carboxylate ester (1).